Results 51 to 60 of about 10,368 (265)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

RANS Modeling of Stably Stratified Turbulent Boundary Layer Flows in OpenFOAM®

E3S Web of Conferences, 2015
Quantifying mixing processes relating to the transport of heat, momentum, and scalar quantities of stably stratified turbulent geophysical flows remains a substantial task. In a stably stratified flow, such as the stable atmospheric boundary layer (SABL),
Wilson Jordan M., Venayagamoorthy Subhas K.   +1 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Response of the Land‐Atmosphere System Over North‐Central Oklahoma During the 2017 Eclipse

Geophysical Research Letters, 2018
On 21 August 2017, a solar eclipse occurred over the continental United States resulting in a rapid reduction and subsequent increase of solar radiation over a large region of the country.
D. D. Turner, V. Wulfmeyer, A. Behrendt, T. A. Bonin, A. Choukulkar, R. K. Newsom, W. A. Brewer, D. R. Cook   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Boundary-layer turbulent processes and mesoscale variability represented by numerical weather prediction models during the BLLAST campaign [PDF]

Atmospheric Chemistry and Physics, 2016
This study evaluates the ability of three operational models, with resolution varying from 2.5 to 16 km, to predict the boundary-layer turbulent processes and mesoscale variability observed during the Boundary Layer Late-Afternoon and Sunset ...
F. Couvreux, E. Bazile, G. Canut, Y. Seity, M. Lothon, F. Lohou, F. Guichard, E. Nilsson   +7 more
doaj   +1 more source

Soft turbulence in the atmospheric boundary layer

AIP Conference Proceedings, 1993
In this work we compare the spectral properties of the daily medium temperature fluctuations with the experimental results of the Chicago Group, in which the local temperature fluctuations were measured in a helium cell. The results suggest that the dynamics of the daily temperature fluctuations is determined by the oft turbulent state of the ...
Jánosi, Imre M., Vattay, Gábor
openaire   +2 more sources

MECHANISM OF WALL TURBULENCE IN BOUNDARY LAYER FLOW [PDF]

Modern Physics Letters B, 2009
The energy gradient method is used to analyze the turbulent generation in the transition boundary layer flow. It is found that the maximum of the energy gradient function occurs at the wall for the Blasius boundary layer flow. At this location under a sufficiently high Reynolds number, even a low level of free-stream disturbance can cause the ...
Dou, Hua-Shu, Khoo, Boo Cheong
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source