Results 51 to 60 of about 34,613 (317)

Submesoscales are a significant turbulence source in global ocean surface boundary layer

Nature Communications
The turbulent ocean surface boundary layer is a key part of the climate system affecting both the energy and carbon cycles. Accurately simulating the boundary layer is critical in improving climate model performance, which deeply relies on our ...
Jihai Dong, Baylor Fox-Kemper, Jacob O. Wenegrat, Abigail S. Bodner, Xiaolong Yu, Stephen Belcher, Changming Dong   +6 more
doaj   +1 more source

Visualization Experiment of Velocity Boundary Layer in Rectangular Channel Using PIV Technique

Yuanzineng kexue jishu, 2023
The plate-type fuel has compact structure and narrow coolant channel. The size effect of large aspect ratio makes the narrow rectangular channel have certain heat transfer enhancement effect, and can meet the requirements of miniaturization, high power ...
ZHANG Yonghao;YU Xiaoyong;LIU Luguo;QIAO Shouxu;TAN Sichao
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On the merging of turbulent spots in a supersonic boundary-layer flow

, 2005
The complex transition flow physics associated with the merging of turbulent spots in a Mach 2 boundary-layer has been studied using direct numerical simulation. Dynamics of an isolated turbulent spot, merging of laterally displaced spots, and merging of
Krishnan, L., Sandham, N.D.
core   +1 more source

Turbulent Kinetic Energy Production in the Vane of a Low-Pressure Linear Turbine Cascade with Incoming Wakes

International Journal of Rotating Machinery, 2015
Incompressible large eddy simulation and direct numerical simulation of a low-pressure turbine at Re=5.18×104 and 1.48×105 with discrete incoming wakes are analyzed to identify the turbulent kinetic energy generation mechanism outside of the blade ...
V. Michelassi, J. G. Wissink
doaj   +1 more source

Sonic Eddy Model of the Turbulent Boundary Layer

Fluids, 2022
The effects of Mach number on the skin friction and velocity fluctuations of the turbulent boundary layer are considered through a sonic eddy model. Originally proposed for free shear flows, the model assumes that the eddies responsible for momentum ...
Paul Dintilhac, Robert Breidenthal
doaj   +1 more source

Boundary-layer turbulence as a kangaroo process [PDF]

Physical Review E, 1995
A nonlocal mixing-length theory of turbulence transport by finite size eddies is developed by means of a novel evaluation of the Reynolds stress. The analysis involves the contruct of a sample path space and a stochastic closure hypothesis. The simplifying property of exhange (strong eddies) is satisfied by an analytical sampling rate model.
Dekker, H., de Leeuw, G., Maassen van den Brin, A.   +2 more
openaire   +5 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Direct numerical simulation of a decelerated wall-bounded turbulent shear flow [PDF]

, 2003
A fully developed turbulent channel flow is subjected to a mean strain that approximates that in a spatially developing adverse-pressure-gradient (APG) boundary layer. This is done by applying uniform irrotational temporal deformations to the flow domain
Coleman, G.N., Spalart, P.R., Kim, J.
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source