Results 81 to 90 of about 455,438 (280)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
On the non-local turbulent transport and non-gradient thermal diffusion phenomena in HVAC systems [PDF]
FME Transactions, 2012 The turbulence structure investigation is essential for understanding the physics of flow-thermodynamic processes in Heating, Ventilation and Air conditioning (HVAC) systems.
Burazer Jela M. +2 more
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Age-Related Vascular Changes Affect Turbulence in Aortic Blood Flow
Frontiers in Physiology, 2018 Turbulent blood flow is implicated in the pathogenesis of several aortic diseases but the extent and degree of turbulent blood flow in the normal aorta is unknown.
Hojin Ha +18 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Simulation of Vertical Plane Turbulent Jet in Shallow Water
Advances in Civil Engineering, 2011 A plane, turbulent, nonbuoyant, vertical jet in shallow water is simulated numerically using a three-dimensional computation model employing standard 𝑘-𝜀 and renormalized group 𝑘-𝜀 turbulent closure schemes.
T. N. Aziz, A. A. Khan
doaj +1 more source
Tribology Online, 2007 This paper presents a general theoretical approach to evaluate the leakage flow, stiffness and damping of annular seals in turbulent flow regime including fluid inertia using turbulent lubrication theory.
Satyam Shivam Gautam, Mihir Kumar Ghosh
doaj +1 more source
Absolute linear instability in laminar and turbulent gas/liquid two-layer channel flow
, 2012 We study two-phase stratified flow where the bottom layer is a thin laminar liquid and the upper layer is a fully-developed gas flow. The gas flow can be laminar or turbulent.
Naraigh, Lennon O. +2 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Turbulent Events and Gas-Side Mass Transfer Coefficients in a Wavy Air-Water Stratified Flow [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2011 Turbulence structure on the gas side of a wavy stratified flow was experimentally investigated in a near horizontal 18.7 cm (H) 10 cm (W) 5.5m (L) rectangular duct.By applying the Variable Interval Time Averaging (VITA) technique to the hot wire ...
Mohsen Nasr Esfahany, Nazi Amanatchi
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