Results 81 to 90 of about 122,095 (310)

A study of mixing and intermittency in a coaxial turbulent jet [PDF]

, 2010
A large eddy simulation study of mixing and intermittency of a coaxial turbulent jet discharging into an unconfined domain has been conducted. The work aims to gain insight into the mixing and intermittency of turbulent coaxial jet configurations. The
Savill, A.M., Jenkins, K.W., Ranga Dinesh, K.K.J., Kirkpatrick, M. P., Savill, Mark A., Jenkins, Karl W., Ranga Dinesh, K. K. J., Kirkpatrick, M.P.   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Turbulent channel flow near maximum drag reduction: simulations, experiments and mechanisms

, 2003
It is well known that the drag in a turbulent flow of a polymer solution is significantly reduced compared to Newtonian flow. Here we consider this phenomenon by means of a direct numerical simulation of a turbulent channel flow.
Hulsen, MA, Brule, van den, B.H.A.A., Hunt, J.C.R., Boersma, BJ, Nieuwstadt, FTM, Nieuwstadt, F.T.M., Hunt, JCR, Hulsen, M.A., Van Den Brule, BHAA, Patasinski, PK, Ptasinski, P.K., Boersma, B.J.   +11 more
core   +1 more source

Multiscale Modeling and Computation of 3D Incompressible Turbulent Flows [PDF]

, 2012
In the first part, we present a mathematical derivation of a closure relating the Reynolds stress to the mean strain rate for incompressible turbulent flows.
Hu, Xin
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Numerical Simulation of a Marine Current Turbine in Turbulent Flow

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorThe marine current turbine (MCT) is an exciting proposition for the extraction of ...
Xin, Bai
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Numerical analysis of flow structures and bed entrainment in turbulent open-channel flow

, 2009
PhDThe results from a Direct Numerical Simulation (DNS) and a Large Eddy Simulation (LES) are employed to study the large-scale coherent structures and bed entrainment in the turbulent open-channel flow.
Ma, Jianmin
core  

Linear non-normal energy amplification of harmonic and stochastic forcing in turbulent channel flow [PDF]

, 2010
The linear response to stochastic and optimal harmonic forcing of small coherent perturbations to the turbulent channel mean flow is computed for Reynolds numbers ranging from Re_tau=500 to Re_tau=20000.
Hwang, Yongyun, Cossu, Carlo, CARLO COSSU, YONGYUN HWANG   +3 more
core   +1 more source