Results 61 to 70 of about 291,257 (303)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Influence of the axial fan blade angle on the turbulent swirl flow characteristics [PDF]
Scientific Technical Review, 2014 The paper presents the investigation of the turbulent swirl flow in a pipe behind the axial fan with adjustable nine blades for the angles of 22°, 26° and 30° for the same rotation number (1500 rpm). Velocities were measured with laser Doppler anemometry
Čantrak Đorđe +3 more
doaj
Spiral structures in turbulent flow [PDF]
, 1993 Spiral structures are natural candidates for the role of the ‘generic structures’ of turbulent flow, because they are the eventual outcome of Kelvin-Helmholtz instability, an all-pervasive phenomenon associated with nearly all shear flows at very high Reynolds number.
openaire +1 more source
Master-modes in 3D turbulent channel flow [PDF]
, 2008 Turbulent flow fields can be expanded into a series in a set of basic functions. The terms of such series are often called modes. A master- (or determining) mode set is a subset of these modes, the time history of which uniquely determines the time ...
Bondarenko, Maksym, Chernyshenko, Sergei
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Grid superfluid turbulence and intermittency at very low temperature [PDF]
, 2016 Low-temperature grid generated turbulence is investigated by using numerical simulations of the Gross-Pitaevskii equation. The statistics of regularized velocity increments are studied. Increments of the incompressible velocity are found to be skewed for
Krstulovic, Giorgio
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Shock and Vibration, 1995 Flow-induced structural noise of a sonar dome in which the sonar transducer is housed, constitutes a major source of self-noise above a certain speed of the vessel.
V. Bhujanga Rao
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source