Results 81 to 90 of about 9,758,243 (289)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Metals, 2018 Large eddy simulation (LES) of transient magnetohydrodynamic (MHD) turbulent flow under a single-ruler electromagnetic brake (EMBr) in a laboratory-scale, continuous-casting mold is presented.
Zhongqiu Liu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Spiral structures in turbulent flow [PDF]
, 1993 Spiral structures are natural candidates for the role of the ‘generic structures’ of turbulent flow, because they are the eventual outcome of Kelvin-Helmholtz instability, an all-pervasive phenomenon associated with nearly all shear flows at very high Reynolds number.
openaire +1 more source
Perturbation Structure and Spectra in Turbulent Channel Flow
Theoretical and Computational Fluid Dynamics, 1998 The spatial wave number/temporal frequency spectra obtained by stochastically forcing the linearized model boundary layer operator associated with wall-bounded shear flow at large Reynolds number are compared with observations of boundary layer turbulence. The verisimilitude of the stochastically excited synthetic turbulence supports the identification
Farrell, B.F., Ioannou, P.J.
openaire +3 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Numerical simulations of drag modulation by microbubbles in a turbulent Taylor-Couette flow [PDF]
, 2013 The aim of our study is to investigate numerically the interaction between a dispersed phase composed of microbubbles and a turbulent Taylor-Couette flow (flow within the gap between two cylinders).
CLIMENT, Eric +3 more
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