Results 41 to 50 of about 7,714 (269)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Heat Transfer Enhancement in a Duct with Two Right Angled Bends [PDF]

Engineering and Technology Journal, 2010
A numerical study was carried out to predict the behavior of complex flow and forced convection heat transfer characteristics in a duct with two right. angled bends for both laminar and turbulent flows. The finite differences method was employed to solve
Jalal M. Jalil, Talib K. Murtadha, Sanaa T. Mousa   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Numerical investigation of turbulent mixed convection flow and heat transfer characteristics of 2 × 2 subchannels with spacer grids

Energy Science & Engineering, 2023
In turbulent mixed convection conditions, flow and heat transfer can deteriorate under specific conditions, thus affecting the performance of the safety of the system, which could imperil the safety of the nuclear reactor. In this paper, by analyzing the
Jianping Long, Bao‐Wen Yang, Ting Wu, Bin Zhang   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Heat Transfer in a Square Ribbed Channel: Evaluation of Turbulent Heat Transfer Models

International Journal of Turbomachinery, Propulsion and Power, 2019
This paper presents the results of integral heat transfer measurements taken in a square ribbed cooling channel configuration for evaluating heat transfer and turbulent flow characteristics in convective cooled gas turbine blades and draws a comparison ...
Beate Wörz, Mark Wieler, Viola Dehe, Peter Jeschke, Michael Rabs   +4 more
doaj   +1 more source

Improved Thermal Performance of a Serpentine Cooling Channel by Topology Optimization Infilled with Triply Periodic Minimal Surfaces

Energies, 2022
The present study utilizes a density-based topology optimization method to design a serpentine channel under turbulent flow, solving a high pressure loss issue and enhancing heat transfer capability. In the topology optimization, the k–ε turbulence model
Kirttayoth Yeranee, Yu Rao, Li Yang, Hao Li   +3 more
doaj   +1 more source

Enhancement and Suppression of Heat Transfer by MHD Turbulence [PDF]

The Astrophysical Journal, 2006
We study of the effect of turbulence on heat transfer within magnetized plasmas for energy injection velocities both larger and smaller that the Alfven speed. We find that in the latter regime the heat transfer is partially suppressed, while in the former regime the effects of turbulence depend on the intensity of driving. In fact, the scale l at which
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Implementation of algebraic turbulent heat flux into Reynolds stress transport model and simulation of crossing tube bundles

Nuclear Engineering and Technology
Lead bismuth eutectic (LBE) is an excellent coolant for fast reactors, owing to its high boiling point and high thermal conductivity. Turbulent heat transfer is a complex phenomenon, and the numerical heat transfer of LBE is constrained by its extremely ...
Han Liu, Hao Sun, Binghuo Yan, Jun Chen, Zhikang Lin   +4 more
doaj   +1 more source