Results 131 to 140 of about 28,958 (312)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The flow structure behind vortex generators embedded in a decelerating turbulent boundary layer [PDF]
, 2009 The objective of the present work is to analyse the behaviour of a turbulent decelerating boundary layer under the effect of both passive and active jets vortex generators (VGs).
Braud, Caroline +3 more
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
The growth of the initially turbulent mixing layer: A large eddy simulation study [PDF]
This article presents new information on the growth of a mixing layer originating from turbulent upstream conditions, obtained through large eddy simulation.
Angelino, M. +2 more
core +1 more source
The local wavenumber model for computation of turbulent mixing. [PDF]
Philos Trans A Math Phys Eng Sci, 2022 Kurien S, Pal N.
europepmc +1 more source
Some issues on turbulent mixing and turbulence
, 1993 Recent data on turbulent mixing suggest that the mixing transition, previously documented to occur in shear layers, also occurs in jets, as well as many other flows, and can be regarded as a universal phenomenon. The resulting, fully-developed turbulent flow requires a minimum Reynolds number of Re_T ≈ 10^4, or a Taylor Reynolds number of Re_T ≈ 10^2 ...
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
EPJ Web of Conferences, 2016 Measurements carried out by the Raman lidar system BASIL are reported to demonstrate the capability of this instrument to characterize turbulent processes within the Convective Boundary Layer (CBL).
Di Girolamo Paolo +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source