Results 121 to 130 of about 28,958 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Jet mixing of water in crude oil pipelines [PDF]

, 1990
The jet mixing of water in crude oil pipelines by single nozzle and multi-nozzle mixers was studied by dividing the mixing domain into to three regions. the penetration. near field and farfield regions.
Fernando, L. M.
core  

Turbulent Flow and Mixing Characteristics in T-Junction

Journal of Fluid Science and Technology, 2011
The flow and temperature/concentration fields in the mixing channel have complex three-dimensional and unsteady natures that are accompanied by flow separations and reattachments, longitudinal vortices, and large-scale velocity fluctuations.
Masafumi HIROTA, Hiroshi NAKAYAMA
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Development of Brown-Roshko structures in the mixing layer behind a splitter plate

, 2008
A direct numerical simulation has been performed of the near field of a mixing layer formed between a high-speed turbulent stream and a low-speed laminar stream. For improved realism, the simulation includes the splitter plate in the computational domain.
Sandberg, Richard D., Sandham, Neil D.
core  

The effect of sudden source buoyancy flux increases on turbulent plumes [PDF]

, 2009
Building upon the recent experimentally verified modelling of turbulent plumes which are subject to decreases in their source strength (Scase et al., J. Fluid Mech., vol. 563, 2006b, p.
SCASE, M. M., Caulfield, C., Scase, M., CAULFIELD, C. P., Aspden, Andrew, ASPDEN, A. J.   +5 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

LES Of intermittency in a turbulent round jet with different inlet conditions [PDF]

, 2010
Large eddy simulation (LES) is a promising technique for accurate prediction of turbulent free shear flows in a wide range of applications. Here the LES technique has been applied to study the intermittency in a high Reynolds number turbulent jet with ...
M.P. Kirkpatrick, Savill, A.M., K.W. Jenkins, Jenkins, K.W., Ranga Dinesh, K.K.J., Kirkpatrick, M. P., A.M. Savill, Savill, Mark A., Jenkins, Karl W., K.K.J. Ranga Dinesh, Ranga Dinesh, K. K. J., Kirkpatrick, M.P.   +11 more
core   +1 more source

The Arctic Ocean Double Estuary: Quantification and Forcing Mechanisms

AGU Advances
The Arctic Ocean double estuary is a “three‐legged” overturning system in which inflowing waters are converted into both lighter and denser waters before being exported equatorwards.
Nikki J. Brown, Alberto C. Naveira Garabato, Sheldon Bacon, Yevgeny Aksenov, Takamasa Tsubouchi, Mattias Green, Ben Lincoln, Tom Rippeth, Daniel L. Feltham   +8 more
doaj   +1 more source