Results 101 to 110 of about 182,785 (292)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Turbulent Flow and Mixing Characteristics in T-Junction

Journal of Fluid Science and Technology, 2011
The flow and temperature/concentration fields in the mixing channel have complex three-dimensional and unsteady natures that are accompanied by flow separations and reattachments, longitudinal vortices, and large-scale velocity fluctuations.
Masafumi HIROTA, Hiroshi NAKAYAMA
doaj   +1 more source

Transient formation of the passive scalar spectrum at a turbulent interface [PDF]

, 2013
We consider the transport of a passive scalar through the turbulent-turbulent interface between two decaying isotropic turbulent flows with different kinetic energy.
Di Savino, Silvio, Gallana, Luca, Iovieno, Michele, Tordella, Daniela   +3 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Turbulent Mixing in Transverse Jets [PDF]

, 2001
Turbulent mixing is studied in liquid-phase transverse jets. Jet-fluid concentration fields were measured using laser-induced fluorescence and digital-imaging techniques, for jets in the Reynolds number range 1000
Dimotakis, Paul, Shan, Jerry
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Buoyant turbulent mixing in shear layers

, 2002
Buoyancy effects in unstably stratified mixing layers express themselves through gravity currents of heavy fluid which propagate in an ambient lighter fluid.
Geurts, Bernard J.
core  

Mass and Momentum Turbulent Transport Experiments [PDF]

, 1983
The downstream mixing of coaxial jets discharging in an expanded duct was studied to improve turbulent transport models which are used in computational procedures throughout the propulsion community for combustor flow modeling. Laser velocimeter (LV) and
Johnson, B. V.
core   +1 more source

Turbulent Convection in Stellar Interiors. II. The Velocity Field

, 2008
We analyze stellar convection with the aid of 3D hydrodynamic simulations, introducing the turbulent cascade into our theoretical analysis. We devise closures of the Reynolds-decomposed mean field equations by simple physical modeling of the simulations (
Arnett, Asida, Balbus, Batchelor, Bethe, Biermann, Boris, Brandenburg, Browning, Browning, Böhm-Vitense, Böhm-Vitense, Campbell, Casey Meakin, Chandrasekhar, Chandrasekhar, Charbonnel, Clayton, Cvitanović, David Arnett, Dutton, Frisch, Gill, Gleick, Hansen, Heger, Howe, Kippenhahn, Kolmogorov, Kritsuk, Landau, Ludwig, Meakin, Meakin, Meakin, Meynet, Nordlund, Oran, Patrick A. Young, Porter, Porter, Shannon, Stone, Sytine, Tassoul, Tennekes, Thompson, Timmes, Trampedach, Tritton, Turner, Vitense, Woodward, Woodward, Young, Zel'dovich   +55 more
core   +1 more source