Results 81 to 90 of about 11,375 (261)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Scalar mixing near the turbulent/non-turbulent interface in the planar liquid jet with chemical reaction

open access: yesNihon Kikai Gakkai ronbunshu, 2019
Chemical reaction near turbulent/non-turbulent (T/NT) interface in liquid phase turbulent flow was investigated experimentally. The concentrations of reactive species near the T/NT interface in a planar liquid jet with a second-order chemical reaction A ...
Koji IWANO   +3 more
doaj   +1 more source

Turbulence and Interfacial Mixing [PDF]

open access: yes, 2005
The authors study mix from analytical and numerical points of view. These investigations are linked. The analytical studies (in addition to laboratory experiments) provide bench marks for the direct simulation of mix. However, direct simulation is too detailed to be useful and to expensive to be practical. They also consider averaged equations.
Glimm, James, Li, Xiaolin
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Turbulent mix experiments [PDF]

open access: yes, 1995
Hydrodynamic instabilities produce material mixing that can significantly degrade weapons performance. We investigate the Richtmyer-Meshkov (RM) and Rayleigh-Taylor (RT) instabilities in the turbulent regime in two experimental venues. RM experiments are conducted on the Nova laser with strong radiatively driven shocks (Mach > 20) in planar, two fluid ...
Dimonte, G., Schneider, M., Frerking, E.
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Broadening of cloud droplet size distributions and warm rain initiation associated with turbulence: an overview

open access: yesAtmospheric and Oceanic Science Letters, 2018
In the study of warm clouds, there are many outstanding questions. Cloud droplet size distributions are much wider, and warm rain is initiated in a shorter time and with a shallower cloud depth than theoretical expectations.
Chun-Song LU   +3 more
doaj   +1 more source

Conditional statistics near the turbulent/non-turbulent interface in a planar liquid jet with a chemical reaction

open access: yesNihon Kikai Gakkai ronbunshu, 2014
We measure concentrations of reactive species and streamwise velocity simultaneously near the turbulent/non-turbulent (T/NT) interface in a planar liquid jet with a second-order chemical reaction A + B → R. The reactants A and B are premixed into the jet
Takahiro NAITO   +4 more
doaj   +1 more source

Some issues on turbulent mixing and turbulence

open access: yes, 1993
Recent data on turbulent mixing suggest that the mixing transition, previously documented to occur in shear layers, also occurs in jets, as well as many other flows, and can be regarded as a universal phenomenon. The resulting, fully-developed turbulent flow requires a minimum Reynolds number of Re_T ≈ 10^4, or a Taylor Reynolds number of Re_T ≈ 10^2 ...
openaire   +2 more sources

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