Results 71 to 80 of about 11,375 (261)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Large eddy simulation on the turbulent mixing phenomena in 3×3 bare tight lattice rod bundle using spectral element method

Nuclear Engineering and Technology, 2020
Subchannel code is one of the effective simulation tools for thermal-hydraulic analysis in nuclear reactor core. In order to reduce the computational cost and improve the calculation efficiency, empirical correlation of turbulent mixing coefficient is ...
Haoran Ju, Mingjun Wang, Yingjie Wang, Minfu Zhao, Wenxi Tian, Tiancai Liu, G.H. Su, Suizheng Qiu   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Variability of turbulent mixing observed by high-resolution Acoustic Doppler Current Profilers in the deep South China Sea

Frontiers in Marine Science
Despite its crucial role in sustaining the global meridional overturning circulation, turbulent mixing remains poorly observed, particularly in the deep ocean.
Hao Xun, Chun Zhou, Chun Zhou, Chun Zhou, Xin Xiao, Shoude Guan, Shoude Guan, Shoude Guan, Xiaodong Huang, Xiaodong Huang, Xiaodong Huang, Tangdong Qu, Wei Zhao, Wei Zhao, Wei Zhao, Jiwei Tian, Jiwei Tian, Jiwei Tian   +17 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Climatic reach of small-scale turbulence in the ocean interior

Nature Communications
Small-scale turbulent mixing in the ocean interior is vital in governing ocean circulation and tracer distributions, and hence global climate. However, the planetary extent of this role and its dependence on the microphysics of mixing remain inadequately
Laura Cimoli, Ali Mashayek, Alberto C. Naveira Garabato, Colm-cille P. Caulfield, Matthew H. Alford, Lois Baker, B. B. Cael, Bieito Fernández Castro, Casimir de Lavergne, Elizabeth Ellison, Geoffrey Gebbie, Jonathan Gula, Patrick Heimbach, Joshua Lanham, Arnaud Le Boyer, Kate Oglethorpe, W. Richard Peltier, Helen R. Pillar, Alexander M. Piotrowski, Sarah G. Purkey, Nick Reynard, Emily Shuckburgh, Martin J. Siegert, Alessandro Silvano, Luke C. Skinner, Carl P. Spingys, Lynne D. Talley, John R. Taylor, Gunnar Voet, Richard G. Williams, Chris Wilson, Bethan L. Wynne-Cattanach   +31 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Mixing of Co-Axial Streams: Effects of Operating Conditions

Journal of Applied Fluid Mechanics, 2016
Present study reports the effects of operating conditions on the mixing of two co-axial streams. Produced mixing layers between the co-axial streams are investigated numerically in the developing regions.
Mohammed A. Azim
doaj   +2 more sources