Results 91 to 100 of about 182,785 (292)

Mixing of Co-Axial Streams: Effects of Operating Conditions

Journal of Applied Fluid Mechanics, 2016
Present study reports the effects of operating conditions on the mixing of two co-axial streams. Produced mixing layers between the co-axial streams are investigated numerically in the developing regions.
Mohammed A. Azim
doaj   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Conditional statistics near the turbulent/non-turbulent interface in a planar liquid jet with a chemical reaction

Nihon Kikai Gakkai ronbunshu, 2014
We measure concentrations of reactive species and streamwise velocity simultaneously near the turbulent/non-turbulent (T/NT) interface in a planar liquid jet with a second-order chemical reaction A + B → R. The reactants A and B are premixed into the jet
Takahiro NAITO, Tomoaki WATANABE, Yasuhiko SAKAI, Kouji NAGATA, Yasumasa ITO   +4 more
doaj   +1 more source

Exploring the possible role of small scale terrain drag on stable boundary layers over land [PDF]

This paper addresses the possible role of unresolved terrain drag, relative to the turbulent drag on the development of the stable atmospheric boundary layer over land.
Holtslag, A.A.M., Mahrt, L., Nappo, C.J., Steeneveld, G.J., Wiel, B.J.H., van de   +4 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Broadening of cloud droplet size distributions and warm rain initiation associated with turbulence: an overview

Atmospheric and Oceanic Science Letters, 2018
In the study of warm clouds, there are many outstanding questions. Cloud droplet size distributions are much wider, and warm rain is initiated in a shorter time and with a shallower cloud depth than theoretical expectations.
Chun-Song LU, Yan-Gang LIU, Sheng-Jie NIU, Yu-Qi XUE   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Coherent structures in a simulated turbulent mixing layer [PDF]

A direct numerical simulation of a plane turbulent mixing layer has been performed. The simulation was initialized using two turbulent velocity fields obtained from direct numerical simulation of a turbulent boundary layer at momentum thickness Reynolds ...
Moser, Robert D., Rogers, Michael M.
core   +1 more source