Results 51 to 60 of about 11,375 (261)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CFD study of the PTS experiment in ROCOM test facility

Nuclear Engineering and Technology, 2020
With the aging of nuclear reactors, embrittlement of the reactor pressure vessel (RPV) steel, as a consequence of routine operations, is highly probable.
Zoran Čarija, Fran Ledić, Ante Sikirica, Bojan Niceno   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Numerical study of turbulent flow under different flow mixing devices in a scaled-down reactor pressure vessel model

Nuclear Engineering and Technology
Turbulent flow in reactor pressure vessel (RPV) of pressurized water reactor (PWR) is complicated because the complex geometry in RPV. The flow rates through fuel assemblies at core inlet are strongly influenced by different designs of flow mixing ...
Wenhai Qu, Hao Xie, Chong Chen, Hanyu Wang, Danhong Shen, Qi Lu, Jian Deng   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effective Diahaline Diffusivities in Estuaries

Journal of Advances in Modeling Earth Systems, 2021
The present study aims to estimate effective diahaline turbulent salinity fluxes and diffusivities in numerical model simulations of estuarine scenarios.
Hans Burchard, Ulf Gräwe, Knut Klingbeil, Nicky Koganti, Xaver Lange, Marvin Lorenz   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Investigation of turbulent/non-turbulent interface and flow topology in turbulent temporally evolving jets

AIP Advances
The turbulent/non-turbulent interface (TNTI) plays a critical role in scalar mixing. Despite extensive previous investigations, outstanding gaps persist in understanding the role of the TNTI and flow topology in turbulent mixing. Those include (i) how to
Dongqi Huang, Wang Han, Yihao Tang, Lijun Yang   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source