Results 41 to 50 of about 5,905 (264)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Turbulence and mixing variability in a microtidal estuary subject to mixed semidiurnal tidal cycles

Frontiers in Marine Science
Reynolds stresses and Turbulent Kinetic Energy (TKE) are instrumental in quantifying the turbulent dynamics that govern mixing and momentum transport in estuaries, factors crucial for understanding and managing estuarine circulation, water quality, and ...
Jan Tiede, Remo Cossu, Jan Visscher, Alistair Grinham, Torsten Schlurmann   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Performance of transported PDF mixing models in a turbulent premixed flame [PDF]

Proceedings of the Combustion Institute, 2017
Abstract Modeling of premixed turbulent flames is challenging due to the effects of strong turbulence-chemistry interaction. In the transported probability density function (TPDF) methods, chemical reactions are treated exactly, while molecular mixing needs to be modeled.
Michael Kuron, Evatt R Hawkes, Zhuyin Ren, Joshua C.K. Tang, Hua Zhou, Jacqueline H. Chen, Tianfeng Lu   +6 more
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The Lifecycle of Tracer Variance in the North Atlantic

Geophysical Research Letters
Oceanic tracer distributions are shaped by turbulent mixing, which may be understood via a traver variance budget. There is a tracer variance lifecycle: variance production by turbulent flows stirring large‐scale gradients, redistribution by currents ...
Espe Broullón, Richard G. Williams, Alberto C. Naveira Garabato, Louis Clément, Bieito Fernández Castro   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Turbulent transport and mixing in the multimode narrowband Richtmyer-Meshkov instability [PDF]

Physics of Fluids, 2019
The mean momentum and heavy mass fraction, turbulent kinetic energy, and heavy mass fraction variance fields, as well as the budgets of their transport equations are examined several times during the evolution of a narrowband Richtmyer-Meshkov instability initiated by a Mach 1.84 shock traversing a perturbed interface separating gases with a density ...
B. Thornber, J. Griffond, P. Bigdelou, I. Boureima, P. Ramaprabhu, O. Schilling, R. J. R. Williams   +6 more
openaire   +2 more sources

Is Turbulence a State of Maximum Energy Dissipation?

Entropy, 2017
Turbulent flows are known to enhance turbulent transport. It has then even been suggested that turbulence is a state of maximum energy dissipation.
Martin Mihelich, Davide Faranda, Didier Paillard, Bérengère Dubrulle   +3 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source