Results 121 to 130 of about 257,752 (298)

Modeling of turbulent transport as a volume process [PDF]

An alternative type of modeling was proposed for the turbulent transport terms in Reynolds-averaged equations. One particular implementation of the model was considered, based on the two-point velocity correlations.
Jennings, Mark J., Morel, Thomas
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Enhanced turbulent transport and drift reduction in divertors at the detachment onset

Nuclear Fusion
At the onset of detachment, measurements show that radial turbulent particle transport $\left(\tilde{\Gamma}_\mathrm{r}\right)$ increases by a factor of $2-4$ above the dissipative region in the near scrape-off layer (SOL) of both single-null (SN) and ...
Rabel Rizkallah, Jose A. Boedo, Cedric K. Tsui, Renato Perillo, the TCV Team   +4 more
doaj   +1 more source

An experimental investigation of the separating/reattaching flow over a backstep [PDF]

Transport characteristics of the turbulent kinetic energy, k, and the shear stream, bar(-uv), were studied in an incompressible boundary layer downstream of the reattachment of the separated flow behind a backward facing step.
Jovic, Srboljub
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Turbulence for (and by) amateurs

, 2000
Series of lectures on statistical turbulence written for amateurs but not experts. Elementary aspects and problems of turbulence in two and three dimensional Navier-Stokes equation are introduced.
Bernard, Denis
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Gyrokinetic simulations of the effects of magnetic islands on microturbulence in KSTAR

Nuclear Fusion
Gyrokinetic simulations are utilized to study effects of magnetic islands (MIs) on the ion temperature gradient (ITG) turbulence in the KSTAR tokamak with resonant magnetic perturbations. Simulations show that the transport is controlled by the nonlinear
Xishuo Wei, Javier H Nicolau, Gyungjin Choi, Zhihong Lin, Seong-Moo Yang, SangKyeun Kim, WooChang Lee, Chen Zhao, Tyler Cote, JongKyu Park, Dmitri Orlov   +10 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source