Results 121 to 130 of about 2,462,893 (295)

Modelling of transport in homogeneous turbulence

Modélisation du transport en turbulence homogène La modélisation est essentielle pour comprendre et reproduire les phénomènes physiques dominants ayant lieu dans des écoulements turbulents naturels (atmosphériques, océaniques). En effet, la dynamique des écoulements géophysiques résulte d'interactions complexes à des échelles et ...
openaire   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Approche PDF jointe fluide-particule pour la modélisation des écoulements turbulents diphasiques anisothermes [PDF]

, 2008
Le contexte général de cette thèse s'inscrit dans le cadre de la modélisation des écoulements turbulents à phase dispersée anisothermes. Les travaux réalisés portent sur la compréhension et la modélisation statistique des mécanismes de transport de ...
Couzinet, Anthony
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characteristics of electroconvection turbulence and proposal of its application to turbulent transport experiment in a rotating spherical shell [PDF]

0000-0002-5892-6047An electroconvection (EC) in liquid crystal is used in the experimental study of turbulent transport. The transport characteristics in EC turbulence were investigated with a planer cell, and the diffusive property of turbulent ...
Kobayashi, Tatsuya, HIDAKA, Y., NAGAOKA, Ken-ichi, HOTTA, S., YOSHIMURA, Yasuo, TERASAKA, Kenichiro, NAGAOKA, Kenichi   +6 more
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reduced electrostatic turbulence in the quasi-isodynamic stellarator configuration CIEMAT-QI4

Nuclear Fusion
CIEMAT-QI4 is a quasi-isodynamic stellarator configuration that simultaneously features very good fast-ion confinement in a broad range of β values, low neoclassical transport and bootstrap current, and ideal magnetohydrodynamic stability up to $\beta ...
J.M. García-Regaña, I. Calvo, E. Sánchez, H. Thienpondt, J.L. Velasco, J.A. Capitán   +5 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

T3ST code: turbulent transport in tokamaks via stochastic trajectories

Nuclear Fusion
We introduce the Turbulent Transport in Tokamaks via Stochastic Trajectories (T3ST) code, designed to address the problem of turbulent transport using a statistical approach complementary to gyrokinetics.
D.I. Palade, L.M. Pomârjanschi
doaj   +1 more source