Results 111 to 120 of about 2,462,893 (295)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Turbulent plasma transport and state of equipartition

, 1999
Turbulent transport may drive a plasma towards a state of Turbulent EquiPartition (TEP). It can be regarded as an attractor with a uniform distribution of Lagrangian invariants respected by the turbulent perturbations in the medium, notably a tokamak ...
Pavlenko, VP,
core  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Strategies for Reduction of Turbulent Viscous Drag

, 2018
In this talks new (and not so new) ideas and strategies, which may help to reduce turbulent viscous drag, will be discussed. Focal point is the wall bounded flow with its characteristic turbulent boundary layer and associated characteristic turbulent ...
Rütten, Markus
core  

Mixing and dispersion in flows dominated by rotation and buoyancy

, 2018
The book presents a state-of-the-art overview of current developments in the field in a way accessible to attendees coming from a variety of fields.
Clercx, H.J.H., van Heijst, Gert Jan F., van Heijst, G.J.F., Clercx, Herman J.H.; id_orcid   +3 more
core   +1 more source

Turbulence and mixing variability in a microtidal estuary subject to mixed semidiurnal tidal cycles

Frontiers in Marine Science
Reynolds stresses and Turbulent Kinetic Energy (TKE) are instrumental in quantifying the turbulent dynamics that govern mixing and momentum transport in estuaries, factors crucial for understanding and managing estuarine circulation, water quality, and ...
Jan Tiede, Remo Cossu, Jan Visscher, Alistair Grinham, Torsten Schlurmann   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Critical roles of edge turbulent transport in the formation of high-field-side high-density front and density limit disruption in J-TEXT tokamak

Nuclear Fusion
This article presents an in-depth study of the sequence of events leading to density limit disruption in J-TEXT tokamak plasmas, with an emphasis on boundary turbulent transport and the high-field-side high-density (HFSHD) front.
Peng Shi, Yuhan Wang, Li Gao, Hongjuan Sun, Qinghu Yang, Xin Xu, Chengshuo Shen, Yanqiu Chen, Qinlin Tao, Zhipeng Chen, Haosheng Wu, Lu Wang, Zhongyong Chen, Nengchao Wang, Zhoujun Yang, Jingchun Li, Yongohua Ding, Yuan Pan, J-TEXT Team   +18 more
doaj   +1 more source