Results 111 to 120 of about 257,752 (298)

Second-order closure models for supersonic turbulent flows [PDF]

Recent work on the development of a second-order closure model for high-speed compressible flows is reviewed. This turbulent closure is based on the solution of modeled transport equations for the Favre-averaged Reynolds stress tensor and the solenoidal ...
Sarkar, Sutanu, Speziale, Charles G.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Numerical Simulation of Sediment Plume Dispersion in Deep-Sea Mining Areas Based on the Similarity Principle

Journal of Marine Science and Engineering
Sediment plumes generated by seafloor mining vehicles represent a major environmental concern in polymetallic nodule harvesting operations. This study investigates plume dispersion induced by sediment disturbances during mining using numerical ...
Lixin Xu, Xiu Li, Yajiao Liu, Zhichao Hong   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Gyrokinetic study of multiple electrostatic and electromagnetic electron-temperature-gradient modes and relevant transport in tokamak finite βe plasmas

Nuclear Fusion
We present a comprehensive study of the multiple electrostatic and electromagnetic electron temperature gradient (ETG) modes with a significant upgrading of the gyrokinetic code HD7.
X.R. Zhang, X. Jian, J.Q. Dong, Z.X. Wang, Y.P. Zou, S. Xu, J. Li, Y.Y. Li, S. Zheng, Q.B. Luan, M.K. Han, R.R. Ma, Y. Shen, W. Chen   +13 more
doaj   +1 more source

Mass and Momentum Turbulent Transport Experiments [PDF]

, 1983
The downstream mixing of coaxial jets discharging in an expanded duct was studied to improve turbulent transport models which are used in computational procedures throughout the propulsion community for combustor flow modeling. Laser velocimeter (LV) and
Johnson, B. V.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Research on stiff transport in electron heating dominated plasmas in EAST

Nuclear Fusion
An experiment was conducted on the Experimental Advanced Superconducting Tokamak (EAST) to investigate the properties of stiff transport in an electron-heated H-mode plasma, using a power deposition scan with electron cyclotron resonance heating (ECRH ...
Jianwen Liu, Yunfeng Liang, Jia Huang, Xiang Gao, Qing Zang, Pan Li, Jiale Chen, Alexander Knieps, Liqing Xu, Xiaohe Wu, Jiahui Hu, Xiaofeng Han, Guangle Lin, Yiqun Li, Yuqi Chu, Haiqing Liu, Bin Zhang, Jinping Qian, Xianzu Gong   +18 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Gyrokinetic simulation of the interplay between ion temperature gradient turbulence and reversed shear Alfvén Eigenmodes

Nuclear Fusion
A nonlinear gyrokinetic simulation, which incorporates both the reversed shear Alfvén eigenmode (RSAE) and the ion temperature gradient (ITG) turbulence, has been performed using the electromagnetic gyrokinetic Particle-In-Cell (PIC) code GEM.
Yuheng Yang, Lei Ye, Yang Chen, Nong Xiang, Youwen Sun   +4 more
doaj   +1 more source