Results 91 to 100 of about 257,752 (298)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A simplified model to estimate nonlinear turbulent transport by linear dynamics in plasma turbulence. [PDF]

Sci Rep, 2023
Nakayama T, Nakata M, Honda M, Narita E, Nunami M, Matsuoka S.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reduced electrostatic turbulence in the quasi-isodynamic stellarator configuration CIEMAT-QI4

Nuclear Fusion
CIEMAT-QI4 is a quasi-isodynamic stellarator configuration that simultaneously features very good fast-ion confinement in a broad range of β values, low neoclassical transport and bootstrap current, and ideal magnetohydrodynamic stability up to $\beta ...
J.M. García-Regaña, I. Calvo, E. Sánchez, H. Thienpondt, J.L. Velasco, J.A. Capitán   +5 more
doaj   +1 more source

Characteristics of constrained turbulent transport in flux-driven toroidal plasmas. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Kishimoto Y, Imadera K, Ishizawa A, Wang W, Li JQ.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Global gyrokinetic simulations of kinetic ballooning mode in NSTX-U plasmas

Nuclear Fusion
Understanding the kinetic ballooning mode (KBM) is crucial for optimizing plasma performance in high- β spherical tokamaks. Global gyrokinetic simulations of KBMs in a projected NSTX-U shot are presented using realistic magnetic geometry and plasma ...
Tajinder Singh, Tariq Rafiq, Eugenio Schuster, Zhihong Lin, Animesh Kuley   +4 more
doaj   +1 more source

Modeling turbulent transport of aerosols inside rooms using eddy diffusivity. [PDF]

Indoor Air, 2021
Venkatram A, Weil J.
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Isotope mix effect on edge turbulent transport in pre-L–H transition conditions in JET-ILW

Nuclear Fusion
The heat flux at the edge of L-mode JET-ILW (Be wall and W divertor) pulses is studied using the gyrokinetic code Gyrokinetic Electromagnetic Numerical Experiment (GENE) in its flux-tube configuration as well as the quasi-linear turbulent transport model
G. Lo-Cascio, N. Bonanomi, C. Angioni, G. Birkenmeier, E.R. Solano, G. Szepesi, JET Contributors, EUROfusion Tokamak Exploitation Team   +7 more
doaj   +1 more source