Results 91 to 100 of about 15,562 (263)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reduced electrostatic turbulence in the quasi-isodynamic stellarator configuration CIEMAT-QI4

Nuclear Fusion
CIEMAT-QI4 is a quasi-isodynamic stellarator configuration that simultaneously features very good fast-ion confinement in a broad range of β values, low neoclassical transport and bootstrap current, and ideal magnetohydrodynamic stability up to $\beta ...
J.M. García-Regaña, I. Calvo, E. Sánchez, H. Thienpondt, J.L. Velasco, J.A. Capitán   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Global gyrokinetic simulations of kinetic ballooning mode in NSTX-U plasmas

Nuclear Fusion
Understanding the kinetic ballooning mode (KBM) is crucial for optimizing plasma performance in high- β spherical tokamaks. Global gyrokinetic simulations of KBMs in a projected NSTX-U shot are presented using realistic magnetic geometry and plasma ...
Tajinder Singh, Tariq Rafiq, Eugenio Schuster, Zhihong Lin, Animesh Kuley   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Isotope mix effect on edge turbulent transport in pre-L–H transition conditions in JET-ILW

Nuclear Fusion
The heat flux at the edge of L-mode JET-ILW (Be wall and W divertor) pulses is studied using the gyrokinetic code Gyrokinetic Electromagnetic Numerical Experiment (GENE) in its flux-tube configuration as well as the quasi-linear turbulent transport model
G. Lo-Cascio, N. Bonanomi, C. Angioni, G. Birkenmeier, E.R. Solano, G. Szepesi, JET Contributors, EUROfusion Tokamak Exploitation Team   +7 more
doaj   +1 more source

Modelling of transport in homogeneous turbulence

Modélisation du transport en turbulence homogène La modélisation est essentielle pour comprendre et reproduire les phénomènes physiques dominants ayant lieu dans des écoulements turbulents naturels (atmosphériques, océaniques). En effet, la dynamique des écoulements géophysiques résulte d'interactions complexes à des échelles et ...
openaire   +4 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Possible seed for internal transport barriers in L-mode plasmas modeled on JT-60U reversed magnetic-shear discharge subject to profile constraints

Nuclear Fusion
We study low confinement mode (L-mode) plasmas modeled on JT-60U reversed magnetic-shear discharges using $\delta f$ -based global gyrokinetic simulations, which exhibit strong profile constraints arising from two spatially separated instability free ...
R. Zhao, K. Imadera, W. Wang, J.Q. Li, Z.X. Wang, A. Ishizawa, Y. Kishimoto   +6 more
doaj   +1 more source