Results 81 to 90 of about 257,752 (298)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Critical roles of edge turbulent transport in the formation of high-field-side high-density front and density limit disruption in J-TEXT tokamak

Nuclear Fusion
This article presents an in-depth study of the sequence of events leading to density limit disruption in J-TEXT tokamak plasmas, with an emphasis on boundary turbulent transport and the high-field-side high-density (HFSHD) front.
Peng Shi, Yuhan Wang, Li Gao, Hongjuan Sun, Qinghu Yang, Xin Xu, Chengshuo Shen, Yanqiu Chen, Qinlin Tao, Zhipeng Chen, Haosheng Wu, Lu Wang, Zhongyong Chen, Nengchao Wang, Zhoujun Yang, Jingchun Li, Yongohua Ding, Yuan Pan, J-TEXT Team   +18 more
doaj   +1 more source

Mass and Momentum Turbulent Transport Experiments [PDF]

An experimental study of mixing downstream of axial and swirling coaxial jets is being conducted to obtain data for the evaluation and improvement of turbulent transport models currently employed in a variety of computational procedures used throughout ...
Johnson, B. V., Roback, R.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Predictive turbulence-driven flux model of scrape-off layer widths across confinement regimes in tokamaks

Nuclear Fusion
Reliable scrape-off layer (SOL) profile decay lengths predictions are needed to design and operate future tokamaks. The present manuscript describes a new model based on turbulent transport that is able to predict SOL widths for both L-mode and H-mode ...
Mathieu Peret, Jerome Guterl, Tess N. Bernard, Federico D. Halpern, Nicolas Fedorczak   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Quasi-linear transport analysis of impurity mode in tokamak plasmas

Nuclear Fusion
The quasilinear turbulent particle and heat transports induced by the impurity mode (IM), driven by the opposite gradients of the core hydrogen and outer $\mathrm{C}^{6+}$ , $\mathrm{O}^{6+}$ , $\mathrm{O}^{8+}$ and $\mathrm{Ne}^{8+}$ ions, are shown to ...
M.K. Han, J.Q. Dong, W. Horton, Z.X. Wang, X.R. Duan, W.L. Zhong, X.L. Zou, A.P. Sun, J. Li, Y. Shen, L.F. Wang   +10 more
doaj   +1 more source

Long-term variations of turbulent transport coefficients in a solar-like convective dynamo simulation

, 2017
The Sun, aside from its eleven year sunspot cycle is additionally subject to long term variation in its activity. In this work we analyse a solar-like convective dynamo simulation, containing approximately 60 magnetic cycles, exhibiting equatorward ...
Gent, Frederick A., Käpylä, Maarit J., Warnecke, Jörn   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source