Results 81 to 90 of about 15,562 (263)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Enhanced turbulent transport and drift reduction in divertors at the detachment onset
Nuclear FusionAt the onset of detachment, measurements show that radial turbulent particle transport $\left(\tilde{\Gamma}_\mathrm{r}\right)$ increases by a factor of $2-4$ above the dissipative region in the near scrape-off layer (SOL) of both single-null (SN) and ...
Rabel Rizkallah +4 more
doaj +1 more source
Focus on dynamics of particles in turbulence
New Journal of Physics, 2014 Studies on the dynamics of particles in turbulence have recently experienced advances in experimental techniques, numerical simulations and theoretical understandings. This ‘focus on’ collection aims to provide a snapshot of this fast-evolving field.
Mickaël Bourgoin, Haitao Xu
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Nuclear FusionReliable scrape-off layer (SOL) profile decay lengths predictions are needed to design and operate future tokamaks. The present manuscript describes a new model based on turbulent transport that is able to predict SOL widths for both L-mode and H-mode ...
Mathieu Peret +4 more
doaj +1 more source
Nuclear Materials and Energy, 2019 A reduced model for radial anomalous transport of plasma in tokamaks, inspired by the Reynolds-Averaged Navier–Stokes (RANS) approach, is presented assuming diffusion as governing mechanism. In order to self-consistently calculate transport coefficients,
S. Baschetti +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Quasi-linear transport analysis of impurity mode in tokamak plasmas
Nuclear FusionThe quasilinear turbulent particle and heat transports induced by the impurity mode (IM), driven by the opposite gradients of the core hydrogen and outer $\mathrm{C}^{6+}$ , $\mathrm{O}^{6+}$ , $\mathrm{O}^{8+}$ and $\mathrm{Ne}^{8+}$ ions, are shown to ...
M.K. Han +10 more
doaj +1 more source
Lateral transport of traffic pollutants in complex urban area
EPJ Web of Conferences, 2018 Owing to the spatial variability of an urban area, even the transport of passive scalar is complex. The examination of the pollutant transport in such turbulent flow as occur within the urban canopy requires the measurements not only the advective but ...
Kluková Zuzana +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source