Results 71 to 80 of about 15,562 (263)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Gyrokinetic study of multiple electrostatic and electromagnetic electron-temperature-gradient modes and relevant transport in tokamak finite βe plasmas

Nuclear Fusion
We present a comprehensive study of the multiple electrostatic and electromagnetic electron temperature gradient (ETG) modes with a significant upgrading of the gyrokinetic code HD7.
X.R. Zhang, X. Jian, J.Q. Dong, Z.X. Wang, Y.P. Zou, S. Xu, J. Li, Y.Y. Li, S. Zheng, Q.B. Luan, M.K. Han, R.R. Ma, Y. Shen, W. Chen   +13 more
doaj   +1 more source

A simplified model to estimate nonlinear turbulent transport by linear dynamics in plasma turbulence. [PDF]

Sci Rep, 2023
Nakayama T, Nakata M, Honda M, Narita E, Nunami M, Matsuoka S.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Research on stiff transport in electron heating dominated plasmas in EAST

Nuclear Fusion
An experiment was conducted on the Experimental Advanced Superconducting Tokamak (EAST) to investigate the properties of stiff transport in an electron-heated H-mode plasma, using a power deposition scan with electron cyclotron resonance heating (ECRH ...
Jianwen Liu, Yunfeng Liang, Jia Huang, Xiang Gao, Qing Zang, Pan Li, Jiale Chen, Alexander Knieps, Liqing Xu, Xiaohe Wu, Jiahui Hu, Xiaofeng Han, Guangle Lin, Yiqun Li, Yuqi Chu, Haiqing Liu, Bin Zhang, Jinping Qian, Xianzu Gong   +18 more
doaj   +1 more source

Characteristics of constrained turbulent transport in flux-driven toroidal plasmas. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Kishimoto Y, Imadera K, Ishizawa A, Wang W, Li JQ.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Gyrokinetic simulation of the interplay between ion temperature gradient turbulence and reversed shear Alfvén Eigenmodes

Nuclear Fusion
A nonlinear gyrokinetic simulation, which incorporates both the reversed shear Alfvén eigenmode (RSAE) and the ion temperature gradient (ITG) turbulence, has been performed using the electromagnetic gyrokinetic Particle-In-Cell (PIC) code GEM.
Yuheng Yang, Lei Ye, Yang Chen, Nong Xiang, Youwen Sun   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source