Results 51 to 60 of about 15,562 (263)

Comparable levels of turbulent and neoclassical transport of high-Z impurities: integrated modelling in AUG, JET and C-Mod

Nuclear Fusion
Operation with beam heating is prone to central accumulation of high- Z impurities in present-day tokamaks due to a dominant neoclassical pinch. Fusion reactors are expected to have a different core transport regime for high- Z impurities, where ...
D. Fajardo, C. Angioni, C. Giroud, C. Perks, A. Loarte, M. Poradzinski, J. Rice, O. Samoylov, I. Carvalho, Z. Huang, D. Keeling, D. King, D. Kos, B. Labit, E. Litherland-Smith, S. Menmuir, N. Vianello, the ASDEX Upgrade Team, JET Contributors, the EUROfusion Tokamak Exploitation Team   +19 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Turbulent drifts of impurity ions as an explanation for anomalous radial transport in the far-SOL of DIII-D

Nuclear Fusion
Successful fusion reactor operation relies on minimal core contamination by impurities, otherwise too much power may be radiated and harm performance. This requires reliable predictions of impurity transport from the scrape-off layer (SOL) into the core,
S.A. Zamperini, T.N. Bernard, D.L Rudakov, J.A Boedo   +3 more
doaj   +1 more source

Ultra long turbulent eddies, magnetic topology, and the triggering of internal transport barriers in tokamaks

Nuclear Fusion, 2022
Local nonlinear gyrokinetic simulations of tokamak plasmas demonstrate that turbulent eddies can extend along magnetic field lines for hundreds of poloidal turns when the magnetic shear is very small.
Arnas Volčokas, Justin Ball, Stephan Brunner   +2 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Transport and modeling of subgrid-scale turbulent kinetic energy in channel flows

AIP Advances, 2022
To develop a more convenient subgrid-scale (SGS) model that performs well even in coarse grid cases, we investigate the transport and modeling of SGS turbulent kinetic energy (hereafter SGS energy) in turbulent channel flows based on the stabilized mixed
Kazuhiro Inagaki, Hiromichi Kobayashi
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source