Results 41 to 50 of about 15,562 (263)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Compatibility of pronounced detachment with improved confinement on HL-2A tokamak

Nuclear Fusion
This paper investigates the compatibility of pronounced detachment with improved confinement based on the NBI-heated HL-2A L-mode plasma with low-density.
Ting Wu, Min Xu, Zhuo Wang, Lin Nie, Zhanhui Wang, Jinming Gao, Yihang Chen, Yiren Zhu, Yi Zhang, Liang Liu, Dong Li, Kai Zhang, Rui Ke, Xiaoxue He, Zengceng Yang, Xin Yu, Na Wu, Zhihui Huang, Kaiyang Yi, Weice Wang, Longwen Yan, Yonggao Li, Ting Long, Renxu Wang, Wenjing Tian, Zhe Wang, Laizhong Cai, Yi Yu   +27 more
doaj   +1 more source

How turbulent transport broadens the heat flux width: local SOL production or edge turbulence spreading?

Nuclear Fusion, 2023
This paper uses data from limited HL-2A Ohmic-plasma to answer the question of how turbulent transport broadens the heat flux width. A key issue in this study is the determination of the origin of scrape-off layer (SOL) turbulence. We develop the concept
T. Wu, P.H. Diamond, L. Nie, M. Xu, Y. Yu, R.J. Hong, Y.H. Chen, J.Q. Xu, T. Long, Y. Zhang, Q.H. Yan, R. Ke, J. Cheng, W. Li, Z.H. Huang, L.W. Yan, X. Chu, Z.H. Wang, C. Hidalgo   +18 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hierarchy of turbulent transport models with the SOLEDGE3X code

Nuclear Fusion
Efficient and fast predictive simulations of turbulent transport in the tokamak edge plasma remain a challenge and are key for preparing the operation and heat exhaust on fusion power plants.
H. Bufferand, M. Capasso, G. Ciraolo, H. Corvoysier, J. Denis, R. Düll, N. Fedorczak, Ph. Ghendrih, E. Havlíčková, I. Kudashev, Y. Marandet, D. Oliveira, N. Rivals, F. Schwander, E. Serre, S. Sureshkumar, P. Tamain, N. Varadarajan, H. Yang, the TCV Team   +19 more
doaj   +1 more source

The ultimate state of convection: a unifying picture of very high Rayleigh numbers experiments

New Journal of Physics, 2020
The long-standing puzzle of diverging heat transport measurements at very high Rayleigh numbers (Ra) is addressed by a simple model based on well-known properties of classical boundary layers.
Philippe-E Roche
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Bounds on Turbulent Transport [PDF]

, 2003
Abstract : The subject of "Bounds on Turbulent Transport" was introduced in a series of ten lectures. The six lecturers constitute almost all of the contributors to this subject. The subject was introduced and foundations were laid by five lectures by F. H. Busse. In the middle of the first week, L. Howard reviewed his historical first approach to this
Peter Constantin, Charles Doering, Louis Howard, Friedrich Busse, John A. Whitehead   +4 more
openaire   +3 more sources

A Statistical Dynamic Model for the Turbulent Transport of Kinetic Energy in Shear Layers

Journal of Aerospace Technology and Management, 2018
Dynamic statistical equations for the turbulent fluxes of scalars and momentum in incompressible flows are derived after time wise integration of the equation for the oscillating transported property, decomposing the turbulent fluxes in terms ...
José Ricardo Figueiredo
doaj