Results 101 to 110 of about 2,462,893 (295)

Surrogate model of transport quantities of gyrokinetic simulations on HL-2A

open access: yesNuclear Fusion
Artificial intelligence techniques, particularly machine learning, are increasingly being employed to reduce the computational cost of high-fidelity fusion simulations.
H.J. Zhao   +4 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

Simulations of edge-flame propagation in turbulent non-premixed jets

open access: yes, 2007
Ignition, flame propagation and stabilisation have been simulated and analysed in a turbulent jet of non-premixed methane and air. The first order Conditional Moment Closure (CMC) turbulent combustion model was fully coupled with a Reynolds-Averaged ...
Richardson, E.S., Mastorakos, E.
core   +1 more source

Quality Measures of Mixing in Turbulent Flow and Effects of Molecular Diffusivity

open access: yesFluids, 2018
Results from numerical simulations of the mixing of two puffs of scalars released in a turbulent flow channel are used to introduce a measure of mixing quality, and to investigate the effectiveness of turbulent mixing as a function of the location of the
Quoc Nguyen, Dimitrios V. Papavassiliou
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

Gyrokinetic simulations of the effects of magnetic islands on microturbulence in KSTAR

open access: yesNuclear Fusion
Gyrokinetic simulations are utilized to study effects of magnetic islands (MIs) on the ion temperature gradient (ITG) turbulence in the KSTAR tokamak with resonant magnetic perturbations. Simulations show that the transport is controlled by the nonlinear
Xishuo Wei   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Wake-Vortex Topology, Circulation, and Turbulent Exchange Processes [PDF]

open access: yes, 2012
Large eddy simulations () of aircraft wake vortex evolution in various turbulent and stably stratified atmospheric environments have been conducted with two different LES codes.
Hennemann, Ingo   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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