Results 101 to 110 of about 2,816,546 (254)

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

A Nonlinear Cross-Diffusion Model for Disease Spread: Turing Instability and Pattern Formation

Mathematics
In this article, we propose a novel nonlinear cross-diffusion framework to model the distribution of susceptible and infected individuals within their habitat using a reduced SIR model that incorporates saturated incidence and treatment rates.
Ravi P. Gupta, Arun Kumar, Shristi Tiwari   +2 more
doaj   +1 more source

alan-turing-institute/netts: 0.3.1

, 2023
Full Changelog: https://github.com/alan-turing-institute/netts/compare/0.3.0...0.3.
Ryan Daniels, Helen Duncan, Caro Nettekoven, SarahMorgan, Oscar T Giles, Iain   +5 more
core   +1 more source

A shining starlet: Nematostella vectensis as a model for developmental, regenerative, and comparative biology

Developmental Dynamics, EarlyView.
Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis, Zachary Horowitz, Michael Shribak, Karen Echeverri   +3 more
wiley   +1 more source

Noise–Seeded Developmental Pattern Formation in Filamentous Cyanobacteria

Life, 2018
Under nitrogen-poor conditions, multicellular cyanobacteria such as Anabaena sp. PCC 7120 undergo a process of differentiation, forming nearly regular, developmental patterns of individual nitrogen-fixing cells, called heterocysts, interspersed between ...
Rinat Arbel-Goren, Francesca Di Patti, Duccio Fanelli, Joel Stavans   +3 more
doaj   +1 more source

alan-turing-institute/TCPDBench: Turing Change Point Benchmark

, 2020
This is an update release of the Turing Change Point Benchmark, corresponding to v2 of the arXiv paper: https://arxiv.org/abs/2003.06222. The Turing Change Point Benchmark is a benchmark study of change point detection algorithms using real-world time ...
Gertjan van den Burg
core   +1 more source

Carbon‐Negative Upcycling of Sewage Sludge into Superiorly Stable Gel Via Liquid‐Phase Utilization Strategy for Water‐Remediation

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work developed a low‐temperature sludge hydrothermal coupled with gel crosslinking strategy which could upgrade the waste liquid generated from sewage sludge hydrothermal treatment into the hydrothermal‐liquid‐gel. The inventive hydrothermal‐liquid‐gel exhibited the enhanced pollutant removal capability, high synthetic stability, and superior ...
Zifan Liu, Sunxinyi Wang, Lingxiao Lu, Weiguo Zhang, Qiang Zheng, Cailiang Yue, Huimin Chang, Xiaohui Lu, Ming Xu, Zhi Qian, Qing Zhou, Fuqiang Liu, Baoshan Xing   +12 more
wiley   +1 more source

Emergence of Diverse Epidermal Patterns via the Integration of the Turing Pattern Model with the Majority Voting Model

Biophysica
Animal skin patterns are increasingly explained using the Turing pattern model proposed by Alan Turing. The Turing model, a self-organizing model, can produce spotted or striped patterns.
Takeshi Ishida
doaj   +1 more source

The Struggle for Authenticity and the Problem of Simulated Narratives

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT The paper discusses the reductionist stance of linguistic AI (e.g., LLMs) and its limitations for self‐narrative work in psychotherapy as an ego‐transformative process of dealing with traumatic life events. Framing AI as a cognition technology aiming to simulate and substitute human cognitive processes/states, it introduces the concept of a ...
Dina Babushkina
wiley   +1 more source

Should Dermatologists Recommend Direct‐to‐Consumer App‐Based Remote Diagnostics? An Ethical Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Dermatology patients still face barriers in accessing timely specialist care. As direct‐to‐consumer (DTC) apps for remote dermatological diagnostics proliferate, guidance is lacking. While promising efficiency and efficacy, their clinical—and ethical—legitimacy is not yet well established.
Sonja Mathes, Sebastian Seurig, Theresa Willem, Marta Dechant, Stephan Traidl, Mina Kang, Pedro Marques Pinto, Annette Binder, Tilo Biedermann, Ulf Darsow   +9 more
wiley   +1 more source