Results 31 to 40 of about 552,176 (210)
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The article discusses several epistemological and methodological issues related to the analysis of discourse in general and of educational talk in particular.
Ivar Solheim
doaj
The use of content and timing to predict turn transitions
For addressees to respond in a timely fashion, they cannot simply process the speaker’s utterance as it occurs and wait till it finishes. Instead, they predict both when the speaker will conclude and what linguistic forms they will use.
Simon eGarrod, Martin J. Pickering
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Conversation is a pivotal spoken discourse needs to be practiced by EFL learners in the classroom. The successful of conversation can be achieved through turn taking strategies as the important part of the conversation.
Rohmatul Fitriyah Dewi +2 more
doaj +1 more source
Managing participation and turn-taking in children’s digital activities
This article investigates touch in the social organization of digital classroom activities as small groups of primary school pupils animate a story by using a shared iPad.
Teppo Jakonen, Kreeta Niemi
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Response to Fred Cummins: Looking for Rhythm in Speech
This commentary briefly reviews three aspects of rhythm in speech. The first concerns the issues of what to measure and how measurements should relate to rhythm's communicative functions.
David House
doaj +1 more source
Competition Reduces Response Times in Multiparty Conversation
Natural conversations are characterized by short transition times between turns. This holds in particular for multi-party conversations. The short turn transitions in everyday conversations contrast sharply with the much longer speech onset latencies ...
Judith Holler +8 more
doaj +1 more source

