Results 61 to 70 of about 566,879 (312)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

ORGANISATION AND ALLOCATION OF TURNS AT THE OPUTA PANEL SESSIONS

Journal of Central and Eastern European African Studies
This study investigates the turn-taking sequence, organisation of turns and the question patterns adopted during the examination of witnesses at the Oputa Panel sessions.
Oluwakemi Olayemi
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Coordinating turn-taking with gaze [PDF]

Proceeding of Fourth International Conference on Spoken Language Processing. ICSLP '96, 1996
Explores the role of gaze in coordinating turn-taking in mixed-initiative conversation, and specifically how gaze indicators might be usefully modeled in computational dialogue systems. We analyzed about 20 minutes of videotape of eight dialogues by four pairs of subjects performing a simple face-to-face cooperative laboratory task.
David G. Novick, Brian Hansen, Karen Ward   +2 more
openaire   +1 more source

The effect of familiarization on temporal aspects of turn-taking: A pilot study [PDF]

, 2010
The organization of conversations with respect to turn-taking and back-channeling is a well-established field of research. Suprasegmental features governing these phenomena have been analyzed regarding both speech production and perception.
Bata, Sarolta, Gráczi, Tekla Etelka
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Conditional Cooperation and Turn-Taking in Parental Care

Frontiers in Ecology and Evolution, 2019
Sexual conflict is inescapable when two parents care for offspring, because providing care is personally costly, while the benefits of successful reproduction are shared.
Rufus A. Johnstone, James L. Savage, James L. Savage   +2 more
doaj   +1 more source

Unpeeling the layers of language: Bonobos and chimpanzees engage in cooperative turn-taking sequences [PDF]

, 2016
Human language is a fundamentally cooperative enterprise, embodying fast-paced and extended social interactions. It has been suggested that it evolved as part of a larger adaptation of humans’ species-unique forms of cooperation.
Froehlich, M, Fruth, B, Furuichi, T, Kuchenbuch, P, Mueller, G, Pika, S, Wittig, RM   +6 more
core   +4 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source