Results 81 to 90 of about 566,879 (312)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
ALIH TUTUR DALAM WACANA INTERAKSI KELAS DI SMP
Lingua: Jurnal Bahasa, Sastra dan Pengajarannya, 2017 The aims of this research is to describe turn taking pattern, adjacency pair, and transition relevance place (TRP). The research used qualitative descriptive method. Data were collected using observation and selected from the classroom interaction at the
Heri Susanto
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
TURN-TAKİNG: TEACHER-STUDENT CONVERSATİON
International Journal of Humanities and Educational Research, 2020 This study aims at showing the types of turn-taking and its relation to cooperative principle and Grician maxims, which organize speech information and duration of speech of the participants. It is hypothesized that the adjacency pair is the dominant type that controls the conversation, and the classroom conversation is a formal conversation rather ...
Mubdir Shihab AHMED, Karama H. HUSSAİN
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
TURN TAKING IN INDONESIA TRADITIONAL MARKE
TRANSFORM: Journal of English Language Teaching and Learning, 2019 This current study aimed to examine the turn-taking strategies that are used by sellers and buyers at Horas traditional market, Pematangsiantar. This study wants to show the process of turn-taking between sellers and buyers when taking their turn. Especially on take the turn when sellers and buyers do bargaining process. It means that which can look at
Simanjuntak, Friska, Meisuri, Meisuri
openaire +2 more sources
Using Turn Taking to Mitigate Conflict and Coordination Problems in the Repeated Battle of the Sexes Game [PDF]
The Battle of the Sexes game, which captures both conflict and coordination problems, has been applied to a wide range of situations. We show that, by reducing conflict of interests and enhancing coordination, (eventual) turn taking supported by a ...
Sau-Him Paul lau, Vai-Lam Mui
core
THE CONVERSATION ANALYSIS OF JON STEWART IN THE AXE FILES [PDF]
, 2016 Alfat Prastowo. 14121330382. The Conversation Analysis of Jon Stewart in The Axe Files. Conversation as human behaviour happens when there are two or more participants who are discussing something.
Alfat Prastowo,
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source