Results 151 to 160 of about 2,570,686 (307)
18th Century Turning Points in U.S. History: 1700-1713
, 2008 1701 The English Board of Trade Creates Royal Colonies1701 The French Return Soldiers to the North American Interior1701 Yale College is Founded1702 Colonists Sack St Augustine1702 Cotton Mather publishes "The Ecclesiastical History of New England."1709 ...
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FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
19th Century Turning Points in U.S. History: 1866-1870
, 2008 1867 ? CARPETBAGGERS DESCEND ON THE SOUTH1867 ? U.S. ACQUIRES ALASKA? SEWARD?S FOLLY1868 ? PRESIDENT JOHNSON IS IMPEACHED1869 ? COMPLETION OF THE TRANS CONTINENTAL RAILROAD1870 ? ROCKEFELLER INCORPORATES STANDARD OIL CO.
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FEBS Open Bio, EarlyView.This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source
Bibliometric Insights in Genetic Factors of Substance-Related Disorders: Intellectual Developments, Turning Points, and Emerging Trends. [PDF]
Front Psychiatry, 2021 Wang K +8 more
europepmc +1 more source
19th Century Turning Points in U.S. History: 1846-1860
, 2008 1846 ? DR.MORTON DEMONSTRATES PAINLESS SURGERY USING ETHER1848 ? GOLD IS DISCOVERED AT SUTTER?S MILL1849 ? TREATY BETWEEN U.S. AND HAWAIIAN ISLANDS1852 ? HARRIET BEECHER STOWE PUBLISHES ?UNCLE TOM?S CABIN?1854 ?
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Turning Points in Prognostic Uncertainty Across the Disease Trajectory For Emerging and Young Adult Caregivers of a Parent with Advanced Cancer. [PDF]
SSM Qual Res HealthKastrinos A +6 more
europepmc +1 more source