Results 41 to 50 of about 1,412,477 (278)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Subjective and Objective Dimensions of Turning Points

open access: yesSocial Work and Society, 2014
The term “turning point” is viewed with great hope. At the same time, it is used with various meanings in research and theory. This leads to a lack of clarity and confusion as to what turning points are.
Daniela Reimer
doaj   +2 more sources

The Riesz basis property of an indefinite Sturm-Liouville problem with non-separated boundary conditions [PDF]

open access: yes, 2013
We consider a regular indefinite Sturm-Liouville eigenvalue problem \{$-f" + q f = \lambda r f$} on $[a,b]$ subject to general self-adjoint boundary conditions and with a weight function $r$ which changes its sign at finitely many, so-called turning ...
Fleige, Andreas   +2 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Turning points identification of growth business cycle in the Czech republic – an alternative approach

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2009
The purpose of the paper is to identify GDP growth cycle of the Czech Republic by means of turning points identification using alternative statistical method – non-parametric kernel estimate.
Jitka Poměnková
doaj   +1 more source

Conceptualising the separation from an abusive partner as a multifactorial, non-linear, dynamic process: A parallel with Newton’s laws of motion

open access: yesFrontiers in Psychology, 2022
The present study focused on the dynamics and factors underpinning domestic abuse (DA) survivors’ decisions to end the abusive relationship. The experiences and opinions of 12 female DA survivors and 18 support workers were examined through in-depth, one-
Daniela Di Basilio   +2 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Modeling and compensation of symmetric hysteresis in piezoceramic actuators

open access: yesResults in Physics, 2019
Based on the well-known Madelung’s rules, a modeling method for the symmetric hysteresis description and compensation of piezoceramic actuators is proposed. The concept of turning point (TP) is introduced in the presented method.
Kairui Cao, Rui Li, Hairui Du, Jing Ma
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

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