Results 81 to 90 of about 1,412,477 (278)
Business confidence and cyclical turning points: A Markov-Switching approach [PDF]
, 2007 Markov regime-switching analysis is used to consider the relationship between business confidence and the probability of turning points in cyclical GDP.
Holmes, Mark J., Silverstone, Brian
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
European Integration – Democracy Promotion by the EU in Eastern Europe [PDF]
, 2007 There have been a few historical turning points in modern European history. The turning points of 1648, 1815, 1919 and 1945 had great impact on the developments of Europe. The last turning point of 1991 is not an exception to such record. The collapse
Silander, Daniel
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Development tendencies and turning points of futures studies
European Journal of Futures ResearchIn honor of its 50th anniversary, the World Futures Studies Federation (WFSF) held its XXV World Conference in Paris. The conference provided a venue for reviewing earlier developments and reevaluating prospective directions in the futures field ...
Tamás Kristóf
doaj +1 more source
Nonparametric Regression and the Detection of Turning Points in the Ifo Business Climate [PDF]
Business climate indicators are used to receive early signals for turning points in the general business cycle. Therefore methods for the detection of turning points in time series are required. Estimations of slopes of a smooth component in the data can
Klaus Abberger
core
Giant Helium Dimers Produced by Photoassociation of Ultracold Metastable Atoms
, 2003 We produce giant helium dimers by photoassociation of metastable helium atoms in a magnetically trapped, ultracold cloud. The photoassociation laser is detuned red of the atomic $2^3S_1 - 2^3P_0 $ line and produces strong heating of the sample when ...
A. P. Mosk +10 more
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source