Results 71 to 80 of about 465,337 (261)

Causes of turnover of professional soldiers of the Serbian Armed Forces [PDF]

Војно дело
Since 1st January 2011, compulsory military service was abolished and transition was made to manning the units of the Serbian Armed Forces with professional members.
Nikolić Dejan Ž.
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Reflection of the economic rate of return in the efficiency use of the fixed and current assets with study case in mettalurgy

Metalurgija, 2014
The companies from the metallurgical industry had had and have the capacity of contributing to the economic development of a country, and one of the most important aspects that have a crucial importance over the evolution and development of these ...
C. Căruntu, L. M. Lăpăduşi
doaj  

Turnover and heterogeneity in top management networks - A demographic analysis of two Swedish business groups [PDF]

International Journal of Business Science and Applied Management, 2008
A theory based on the demography of top management teams is used to explain membership turnover in two Swedish business groups, network analysis being used to define group membership.
Collin, S. & Umans, T.
doaj  

Turnover Dynamics of Breeding Land Birds on Islands: is Island Biogeographic Theory ‘True but Trivial’ over Decadal Time-Scales?

Diversity, 2017
The theory of island biogeography has revolutionised the study of island biology stimulating considerable debate and leading to the development of new advances in related areas.
Duncan McCollin
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

The Impact of Land-Use Change on the Diversity of Soil Macroinvertebrates in Rangelands and Hand-Planted Forests (Lavizan Forest Park, Tehran, Iran) [PDF]

محیط زیست و توسعه فرابخشی
Introduction: Rational use and protection of natural grasslands within legal frameworks to regulate rangeland management and prevent land degradation, especially in countries with extensive grasslands, are crucial. Land-use change from grasslands to hand-
Maryam Azimi bidar, Faraham Ahmadzadeh, Khosro Piri, Asghar Abdoli, Reihaneh Saberi-Pirooz   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source