Results 81 to 90 of about 757,961 (297)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Turnover Processes in a Temporal Context: It's About Time [PDF]
To better understand the process of organizational withdrawal, a turnover model incorporating dynamic predictors measured at five distinct points in time was examined by following a large, occupationally diverse sample over a two-year period.
Theresa M. Glomb +3 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
DETERMINANTS OF TURNOVER INTENTIONS AMONG CHINESE OFF FARM MIGRANTS [PDF]
This study examines the determinants of turnover intentions of off farm migrant workers, using data collected from China's Jiangsu Province. Turnover intention is posited to be a function of demographic/human capital characteristics, job characteristics ...
Qingguo Zhai, Russell Smyth, Xiaoxu Li
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
DETERMINANTS OF OUTSIDE DIRECTOR TURNOVER [PDF]
In this paper we provide evidence that independent director turnover is influenced by a series of economic factors. Directors, both independent and insider, are less likely to leave if they are paid well or if the firm has a director pension plan.
Sharad Asthana, Steven Balsam
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Frontiers in Cellular NeuroscienceOlfactory dysfunction (OD) is one of the important and difficult-to-treat symptoms of eosinophilic chronic rhinosinusitis (CRS), which is typically associated with type 2 inflammation where eosinophils (EOSs) function as both effectors and initiators ...
Yuetong Chen, Minghan Li, Juan Lu
doaj +1 more source
Causes of turnover of professional soldiers of the Serbian Armed Forces [PDF]
Војно делоSince 1st January 2011, compulsory military service was abolished and transition was made to manning the units of the Serbian Armed Forces with professional members.
Nikolić Dejan Ž.
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Stock Option Compensation and Managerial Turnover [PDF]
This study examines the association between managerial turnover and equity-based compensation. I investigate whether stock options act to bond executives to their firms and whether retention of managers is a motivation of companies in designing CEO ...
Raluca Georgiana NASTASESCU
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