Results 201 to 210 of about 239,095 (307)

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Workplace Gaslighting Is Associated with Nurses' Job Burnout and Turnover Intention in Greece. [PDF]

Healthcare (Basel)
Moisoglou I, Katsiroumpa A, Konstantakopoulou O, Papathanasiou IV, Katsapi A, Prasini I, Chatzi M, Galanis P.   +7 more
europepmc   +1 more source

Fe/N‐Doped Carbon with Nearly Ordered Mesopores and Tunable Particle Sizes as Model Catalysts for Quantitative Evaluation of Electrocatalytic Active Sites

Advanced Science, EarlyView.
This study is dedicated to the design and synthesis of MOF‐derived mesoporous Fe/N‐doped carbons as model catalysts, aiming to quantitatively evaluate the utilization of active sites in the ORR. Through modulation followed by pyrolysis, we successfully prepare size‐tunable Fe/MNC‐x with doped iron atoms and mesoporous structures. The smaller Fe/MNC‐250
Hongjuan Zhang, Yunqi Li, Jiacheng Zhao, Yue Liu, Xingtao Xu, Yusuke Yamauchi, Jing Tang, Min Zhou   +7 more
wiley   +1 more source

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

Association between nursing work environment, burnout, and turnover intention: A cross-sectional study in Greece. [PDF]

AIMS Public Health
Moisoglou I, Katsiroumpa A, Fradelos EC, Papathanasiou IV, Paralikas T, Prasini I, Rekleiti M, Katsapi A, Chatzi M, Galanis P.   +9 more
europepmc   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Overview of the prevalence of job satisfaction and turnover intention among emergency medical services personnel: a meta-analysis. [PDF]

J Glob Health
Huang G, Hung WK, Ngolombe R, Maona C, Chiona BC, Banda KJ.   +5 more
europepmc   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Impact of Nurses' Peak Workload and Time Pressure on Work Exhaustion and Turnover Intention. [PDF]

J Nurs Manag
Chang HY, Lin YA, Yu WP, Wu HH, Liao GY, Rudman A, Teng CI.   +6 more
europepmc   +1 more source

Antecedents of Turnover Intention: A Relationship Model for Predicting Turnover Intention

Didin Hikmah Perkasa, Ovi Hamidah Sari
openaire   +1 more source