Results 61 to 70 of about 6,969,201 (284)

The influence of membrane composition on the release of polyphenols from liposomes [PDF]

Hemijska Industrija, 2015
Polyphenols are compound which are widely studied because of their antioxidative and potential therapeutic properties. Systems for the controlled release of drugs offer a number of benefits comparing with traditional forms of medicines and ...
Pravilović Radoslava N., Radunović Vesna S., Bošković-Vragolović Nevenka M., Bugarski Branko M., Pjanović Rada V.   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Stability and Kinetic Study of Vitamin C containing Hydrogenated and Middle-Chain Triglyceride Coconut Oil-Based Double Emulsion

International Journal of Technology
Vitamin C or ascorbic acid, is an organic compound that is highly required by human since it acts as antioxidant, help increase metabolism, and improves the immune system. Vitamin C is easily oxidized and damaged during storage due to several external
Lanny Sapei, Emma Savitri, Ignasius Radix A.P. Jati, Rochmad Indrawanto, Hillary Emmanuella Darsono, Yenni Anggraeni, Cindy Sumampouw   +6 more
doaj   +1 more source

Freeze assisted-aqueous extraction of rapeseed oil using Tween 20 [PDF]

The traditional oil extraction methods often rely on organic solvents, raising environmental and health concerns, while aqueous extraction offers a potentially greener alternative.
Alimari, Ibrahim, Abbasi, Soleiman
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Design of Delivery Systems (Nanoemulsions and Biopolymer Nanoparticles) of Cloves Essential Oil: Preparation, Characterizations, Study the Release, and Antioxidant Activity

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
BACKGROUND: Clove oil has a wide range of therapeutic and pharmaceutical applications. It is also used in the manufacture of pesticides and antifungals, as well as many advantages.
Mariam Kadhim Taher, Israa Qusay Falih, Younus Jasim Abdullah   +2 more
doaj   +1 more source

Study of Lipase Producing Bacterial Strains from Oil Contaminated Soil

Journal of Basic and Applied Research in Biomedicine, 2022
Lipase producing bacterial strains were isolated from oil contaminated soils and grown on nutrient agar medium containing 1% (w/v) Tween-20. The isolate showing maximum activity was identified by following Berger’s manual.
Chitra Bhattacharya, Bhawana Pandey, Ashis Sarkar   +2 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Prolonged Tween-20 treatment leads to apoptosis.

, 2013
HeLa cells were incubated in serum-free DMEM (Untreated), serum-free DMEM containing 150 µM Tween-20, or serum-free DMEM containing 25 µM etoposide. The cells were harvested at the time points indicated, lysed and 40 µg of cell lysate was separated by ...
Jacqueline B. Pierce (312676), Dev Mangroo (312679), Shawn C. Chafe (312674)   +2 more
core   +1 more source