Results 241 to 250 of about 2,457,689 (293)

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

From Flow to Function: Using Different Static Mixers to Fabricate Microarchitected Materials Via Chaotic Printing

Advanced Science, EarlyView.
Complex microarchitectures emerge from simple flow‐driven transformations as static mixers iteratively reorient and split material domains. Coupled with diverse deposition strategies, chaotic printing provides an accessible platform for fabricating architected materials that support biologically and chemically relevant processes. ABSTRACT Nature builds
Edna Johana Bolívar‐Monsalve, Carlos Fernando Ceballos‐González, Diego Alonso Quevedo‐Moreno, Irving Isaí Rendón‐Moreno, Ariel Cantoral‐Sánchez, Héctor Ambriz‐González, Mario Moisés Alvarez, Grissel Trujillo‐de Santiago   +7 more
wiley   +1 more source

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Effects of Tween 20® and Tween 80® on the Stability of Albutropin During Agitation

Journal of Pharmaceutical Sciences, 2005
The objectives of this work were to determine the effects of nonionic surfactants (Tween 20 and Tween 80) on agitation-induced aggregation of the recombinant fusion protein, Albutropintrade mark (human growth hormone genetically fused to human albumin), and to characterize the binding interactions between the surfactants and the protein.
Rajesh Krishnamurthy, Theodore Randolph, Mark Cornell Manning   +2 more
exaly   +3 more sources

Dual effects of Tween 80 on protein stability

International Journal of Pharmaceutics, 2008
In this paper, we used IL-2 mutein as a model protein and evaluated the effect of Tween 80, a non-ionic surfactant. In summary, we found that the dual effects of Tween 80 on the stability of IL-2SA, such as that shaking-induced aggregation of IL-2 mutein was significantly inhibited in the presence of Tween 80.
D Q Wang
exaly   +3 more sources

Enhancement of the Antitumor Activity of Adriamycin by Tween 80

Tumori Journal, 1978
This paper describes the effect of Tween 80 on the antitumor activity and on the distribution of adriamycin in mice. The dilution of adriamycin in a 10% water solution of Tween 80 produced a significant increase of the antitumor activity in mice against ascites tumors (L1210 leukemia), disseminated leukemias (transplanted leukemias originally induced ...
A M, Casazza, G, Pratesi, F, Giuliani, F, Formelli, A, Di Marco   +4 more
openaire   +3 more sources

Complex Micellization Behavior of the Polysorbates Tween 20 and Tween 80

Molecular Pharmaceutics, 2021
Polysorbates (PSs, Tweens) are widely used surfactant products consisting of a sorbitan ring connecting up to four ethylene oxide (EO) chains of variable lengths, one or more of which are esterified with fatty acids of variable lengths and saturation degrees.
Hannah Knoch, Maximilian H. Ulbrich, Judith J. Mittag, Julia Buske, Patrick Garidel, Heiko Heerklotz   +5 more
openaire   +3 more sources

The Effect of “Tween-65” and “Tween-80” on Gastrointestinal Motility in Man

Gastroenterology, 1953
Summary 1.The effect on gastrointestinal motility of ingesting 9 gm. of either Tween65 or Tween-80 for 13 successive days was studied in 24 normal individuals, and was compared with equal amounts of a placebo under similar conditions. 2.No subjective reactions or changes in bowel habit, character of stools, and body weight were induced by 117 gm ...
H D, JANOWITZ, F, HOLLANDER, R H, MARSHAK   +2 more
openaire   +2 more sources

Comparative Analysis of the Properties of Tween‐20, Tween‐60, Tween‐80, Arlacel‐60, and Arlacel‐80

Journal of Dispersion Science and Technology, 2007
Foamability and foam stability, emulsifying power, surface tension, and interfacial tension were investigated for Tween‐20 (polyoxyethylene sorbitan monolaurate), Tween‐60 (polyoxyethylene sorbitan monostearate), Tween‐80 (polyoxyethylene sorbitan monooleate), Arlacel‐60 (Sorbitan stearate), and Arlacel‐80 (Sorbitan oleate).
Shrinivas C. Kothekar, Adinath M. Ware, Jyotsna T. Waghmare, S. A. Momin   +3 more
openaire   +1 more source