Results 131 to 140 of about 2,453,712 (230)

Intelligent Continuum Micromachines in Complex Confined Spaces

open access: yesSmartBot, EarlyView.
The cover depicts a conceptual design for an intelligent continuum micromachine entering a target capsule used in fusion‐energy research through its slender gas‐fill tube. By combining route‐adaptive deformation, embedded sensing, and a functional end effector, the robot could inspect hidden defects, assess local conditions, and support localized ...
Huayang Sai   +7 more
wiley   +1 more source

Management of Twin Reversed Arterial Perfusion Sequence: A Systematic Review and Meta-Analysis.

open access: yes
INTRODUCTION: Twin reversed arterial perfusion (TRAP) sequence is a rare complication of monochorionic twin pregnancies characterized by placental anastomoses between a normally developed twin and an acardiac mass.
Christensen, Leslie   +9 more
core   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

open access: yesSmart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang   +8 more
wiley   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

open access: yesSmart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

open access: yesSusMat, EarlyView.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang   +12 more
wiley   +1 more source

Hemodynamic Effects of Prolonged Apneic Oxygenation in Laryngologic Surgery: A Randomized Controlled Pilot Trial

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Limited data exist on cardiocirculatory responses associated with extended periods of apnea during administration of high‐flow nasal oxygen for laryngologic surgery (apneic oxygenation with HFNO, AO‐HFNO). The possibility of hemodynamic compromise in the settings of acute hypercapnia, respiratory acidosis, hyperoxia, and IV ...
Vladimir Nekhendzy   +6 more
wiley   +1 more source

Monitoring Mitochondrial Function With High‐Resolution Respirometry During Ex‐Situ Heart Perfusion

open access: yesArtificial Organs, EarlyView.
Normothermic ESHP preserves mitochondrial respiratory function over 6 h in a porcine model (n = 6): OXPHOS capacities across NADH‐, fatty‐acid‐, and succinate‐linked pathways remain stable, with reduced cytochrome‐c control efficiency indicating improved outer‐membrane integrity. HRR provides a rapid, actionable readout for organ assessment.
Lukas Stastny   +12 more
wiley   +1 more source

Adult‐onset Coats disease: A systematic review and meta‐analysis of imaging biomarkers and targeted therapies

open access: yesActa Ophthalmologica, EarlyView.
Abstract Coats disease diagnosed in adulthood is a rare idiopathic retinal telangiectatic vasculopathy that may differ in phenotype from childhood‐diagnosed cases. This systematic review synthesizes current evidence to characterize its clinical spectrum, imaging features, treatment outcomes and underlying mechanisms, with a focus on immunovascular ...
Catarina Francisco   +2 more
wiley   +1 more source

Scholars Journal of Medical Case Reports ISSN 2347-9507 (Print) Twin Reversed Arterial Perfusion Sequence (TRAP Sequence) -The Acardiac/ Acephalic Twin: A Case Report

open access: yes, 2015
: Twin Reversed Arterial Perfusion is an unusual form of twin to twin transfusion syndrome (TTTS) occurring in monochorionic twin pregnancies. There is an artery to artery or vein to vein communication between both the twins.
Prathyusha   +3 more
core  

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

open access: yesBrain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen   +8 more
wiley   +1 more source

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