Results 31 to 40 of about 2,169,353 (266)

Molecular model of a sensor of two-component signaling system

Scientific Reports, 2021
Two-component systems (TCS) are widespread signaling systems present in all domains of life. TCS typically consist of a signal receptor/transducer and a response regulator.
Yury L. Ryzhykau, Philipp S. Orekhov, Maksim I. Rulev, Alexey V. Vlasov, Igor A. Melnikov, Dmytro A. Volkov, Mikhail Yu. Nikolaev, Dmitrii V. Zabelskii, Tatiana N. Murugova, Vladimir V. Chupin, Andrey V. Rogachev, Andrey Yu. Gruzinov, Dmitri I. Svergun, Martha E. Brennich, Ivan Yu. Gushchin, Montserrat Soler-Lopez, Arne Bothe, Georg Büldt, Gordon Leonard, Martin Engelhard, Alexander I. Kuklin, Valentin I. Gordeliy   +21 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Diversity of two-component systems: insights into the signal transduction mechanism by the Staphylococcus aureus two-component system GraSR [PDF]

F1000Research, 2014
The response to cationic antimicrobial peptides (CAMPs) in Staphylococcus aureus relies on a two-component system (TCS), GraSR, an auxiliary protein GraX and an ATP-binding cassette (ABC) transporter, VraF/G. To understand the signal transduction mechanism by GraSR, we investigated the kinase
Muzamal, Uzma, Gomez, Daniel, Kapadia, Fenika, Golemi-Kotra, Dasantila   +3 more
openaire   +3 more sources

Defining the role of Pseudomonas aeruginosa PilY1 in signaling and virulence

Journal of Bacteriology
Pseudomonas aeruginosa (Pa) is an important opportunistic pathogen that has many virulence factors expressed in a coordinated manner to cause infection.
Christopher L. Pritchett, F. H. Damron, M. Barbier   +2 more
doaj   +1 more source

The SaeRS Two-Component System Controls Survival of Staphylococcus aureus in Human Blood through Regulation of Coagulase

Frontiers in Cellular and Infection Microbiology, 2017
The SaeRS two-component system plays important roles in regulation of key virulence factors and pathogenicity. In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation of the
Haiyong Guo, Haiyong Guo, Jeffrey W. Hall, Junshu Yang, Yinduo Ji   +4 more
doaj   +1 more source

Roles of histidine kinase gene yycg in the pathogenicity of listeria monocytogenes [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020
As an opportunistic foodborne pathogen, Listeria monocytogenes could successfully switch self-characteristics in response to environmental conditions. In L. monocytogenes, sixteen two-component systems (TCSs) have been found to contribute the bacteria to
Xiaowei FANG, Wei HU, Yu ZHANG, Chen WANG, Qingping LUO, Hui WU, Xiongyan LIANG, Yufang GU, Chun FANG, Yuying YANG   +9 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Mapping the ‘Two-component system’ network in rice [PDF]

Scientific Reports, 2017
AbstractTwo-component system (TCS) in plants is a histidine to aspartate phosphorelay based signaling system. Rice genome has multifarious TCS signaling machinery comprising of 11 histidine kinases (OsHKs), 5 histidine phosphotransferases (OsHPTs) and 36 response regulators (OsRRs). However, how these TCS members interact with each other and comprehend
Ashutosh Sharan, Praveen Soni, Ramsong Chantre Nongpiur, Sneh L. Singla-Pareek, Ashwani Pareek   +4 more
openaire   +2 more sources

Phosphatase activity tunes two-component system sensor detection threshold

Nature Communications, 2018
Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific point ...
Brian P. Landry, Rohan Palanki, Nikola Dyulgyarov, Lucas A. Hartsough, Jeffrey J. Tabor   +4 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source