Results 41 to 50 of about 2,123,405 (317)
Defining the role of Pseudomonas aeruginosa PilY1 in signaling and virulence
Journal of BacteriologyPseudomonas aeruginosa (Pa) is an important opportunistic pathogen that has many virulence factors expressed in a coordinated manner to cause infection.
Christopher L. Pritchett +2 more
doaj +1 more source
New Insights into the Non-orthodox Two Component Rcs Phosphorelay System
Frontiers in Microbiology, 2017 The Rcs phosphorelay system, a non-orthodox two-component regulatory system, integrates environmental signals, regulates gene expression, and alters the physiological behavior of members of the Enterobacteriaceae family of Gram-negative bacteria.
Xiao-Peng Guo, Yi-Cheng Sun
doaj +1 more source
Clinical Insights Into Hypercalcemia of Malignancy in Childhood
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 The SaeRS two-component system plays important roles in regulation of key virulence factors and pathogenicity. In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation of the
Haiyong Guo +4 more
doaj +1 more source
A two-component system regulates hemin acquisition in Porphyromonas gingivalis. [PDF]
PLoS ONE, 2013 Porphyromonas gingivalis is a Gram-negative oral anaerobe associated with infection of the periodontia. The organism has a small number of two-component signal transduction systems, and after comparing genome sequences of strains W83 and ATCC 33277 we ...
Jodie C Scott +4 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine +14 more
wiley +1 more source
Phosphatase activity tunes two-component system sensor detection threshold
Nature Communications, 2018 Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific point ...
Brian P. Landry +4 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011 Procedure of calculation of three- and four-component eutectic system temperature and composition on the basis of two-component systems known characteristics and the initial substances known melting-points is introduced.
Olga S Afanasieva, Galina F Egorova
doaj
Biomolecules, 2020 Although it has long been known that bacteria detect and react to plant chemicals to establish an interaction, the cellular signaling mechanisms involved in these perception processes have hitherto remained obscure.
Samar Kabbara +6 more
doaj +1 more source