Results 81 to 90 of about 20,875,315 (249)

Heat dissipation study of graphene-based film in single tube IGBT devices

AIP Advances, 2019
The insulated gate bipolar transistor (IGBT) devices often work under significantly high voltage and current, and how to reduce loss within them and prevent damage to them, caused by excessive heating must be considered in their operation. In this paper,
Yuan Xu, Jie Bao, Renxia Ning, Zhenhai Chen, Wenyi Xu   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

In situ synthesis of large-area sixfold-oriented Mo6Te6 nanowires networks through hydrogen-assisted annealing of 2H MoTe2 nanosheets

Nano Research
Phase transition and edge structure reconstruction of two-dimensional (2D) materials are critical for modulating their properties and applications. Here, we employ a hydrogen-assisted annealing method to accomplish the extensive transformation from a 2H ...
Ying Huangfu, Ping Lu, Jiang Zhong, Qiankun Zhang, Jingyi Liang, Zhengwei Zhang, Biao Qin, Zucheng Zhang, Ziwei Huang, Wei Li, Kun He, Xiaohui Lin, Xiangdong Yang, Jia Li, Bo Li, Weiyou Yang, Zhang Lin, Liyuan Chai, Xidong Duan   +18 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Revisiting Batchelor's theory of two-dimensional turbulence [PDF]

, 2007
Recent mathematical results have shown that a central assumption in the theory of two-dimensional turbulence proposed by Batchelor (Phys. Fluids, vol. 12, 1969, p. 233) is false.
Tran, Chuong Van, K. Scott, Scott, Richard Kirkness, David G. Dritschel, Chuong V. Tran, Richard, Dritschel, David Gerard   +6 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Synthesis, crystal structure and properties of YB2C2

Journal of Asian Ceramic Societies
YB2C2 is a novel ultra-high temperature ceramic material with high damage tolerance. In this work, the synthesis mechanism, crystal structure, electronic structure, elastic properties and thermal shock resistance of YB2C2 were systematically investigated
Yueming Li, Depeng Ji, Yiwang Bao, Jixin Chen, Hui Zhang, Guorui Zhao   +5 more
doaj   +1 more source

Two-dimensional magnetohydrodynamic turbulence in the small magnetic Prandtl number limit [PDF]

, 2012
In this paper we introduce a new method for computations of two-dimensional magnetohydrodynamic (MHD) turbulence at low magnetic Prandtl number $\Pra=\nu/\eta$.
Tobias, Steve, Dritschel, David Gerard
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source