Results 191 to 200 of about 19,563,565 (291)

FGF21/sirtuin 1 axis mediates the cardioprotective effects of high‐intensity interval training against doxorubicin‐induced cardiotoxicity by reducing inflammatory and oxidative stress

open access: yesExperimental Physiology, EarlyView.
Abstract Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent, but its clinical use is limited by cumulative cardiotoxicity. Exercise, particularly high‐intensity interval training (HIIT), has emerged as an effective non‐pharmacological strategy to counteract chemotherapy‐induced cardiac injury.
Mahdiyeh Farahani   +3 more
wiley   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

open access: yesExperimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh   +12 more
wiley   +1 more source

A new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk‐factor modification in atrial fibrillation

open access: yesExperimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley   +1 more source

Galectin‐3 plasma levels are associated with left atrial contractile function in long‐distance runners

open access: yesExperimental Physiology, EarlyView.
Abstract High‐intensity endurance exercise induces myocardial remodelling as an adaptive response to sustained volume overload, but excessive cumulative training might also favour deleterious cardiac remodelling, including atrial fibrosis. Whether acute marathon running engages circulating fibrosis‐related biomarkers and whether these biomarkers track ...
Felipe Contreras‐Briceño   +6 more
wiley   +1 more source

The impact of biological sex and stroke volume constituents on heterogeneity in the Q̇$\dot{Q}$–V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$ relationship and skeletal muscle saturation during cycling

open access: yesExperimental Physiology, EarlyView.
Abstract Interindividual variability in the cardiac output (Q̇$\dot{Q}$) to the rate of oxygen consumption (V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$) slope (Q̇$\dot{Q}$–V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_2}}}$) in healthy males is related to stroke volume (SV); however, the impact of differences in left ventricular (LV) structure and function as well as ...
Adam N. Di Salvo   +4 more
wiley   +1 more source

Enhancing stroke risk stratification in atrial fibrillation through non‐Newtonian blood modelling and Gaussian process emulation

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Non‐Newtonian modelling and GPEs for stroke risk in atrial fibrilation patients. Abstract Atrial fibrillation (AF) is the most common heart arrhythmia, linked to a five‐fold increase in stroke risk. The left atrial appendage (LAA), prone to blood stasis, is a common thrombus formation site in AF patients.
Paolo Melidoro   +12 more
wiley   +1 more source

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