Results 91 to 100 of about 788,319 (263)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Generalizable growth of 2D twisted transition metal dichalcogenide heterostructures under non-equilibrium thermodynamic conditions

Nature Communications
Twisted two-dimensional (2D) transition metal dichalcogenide (TMD) structures have emerged as a versatile platform for optoelectronics and quantum materials, but their controlled bottom-up synthesis remains challenging.
Qiuyin Qin, Xin Li, Wei Li, Wangpeng Chen, Shihao Zhang, Shula Chen, Ziyu Luo, Zhiwen Hua, Liqiang Zhang, Wenhao Xi, Wenjing Xie, Dingyi Shen, Bo Li, Yuan Liu, Jia Li, Ruixia Wu, Xidong Duan   +16 more
doaj   +1 more source

Optical Interference Substrates for Nanoparticles and Two-Dimensional Materials

Nanomaterials and Nanotechnology, 2013
Interference substrates are useful in enhancing Raman and luminescence signals and in increasing the optical contrast of nanoparticles and atomically thin layers. Interference substrates played a crucial role in the discovery of the electric field effect
Wolfgang S Bacsa, Ekaterina Pavlenko, Victoria Tishkova   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Two dimensional superconductors in electrides

New Journal of Physics, 2017
Two-dimensional (2D) superconductors are always a research hotspot in superconductivity, due to the huge importance of 2D superconductors in quantum phenomena transitions.
Yanfeng Ge, Shan Guan, Yong Liu
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Fabrication of two-dimensional polymers and two-dimensional materials

, 2016
Die vorliegende Arbeit beinhaltet drei unterschiedliche Ansätze zur Herstellung neuer zweidimensionaler Polymere bzw. zweidimensionaler Materialien. Im ersten Teil werden zwei verschiedene Methoden zur nichtkovalenten Assemblierung beschrieben zur Herstellung groß-flächiger Einzelmoleküllagen.
openaire   +4 more sources

The Two-Dimensional Argument against Materialism [PDF]

, 2009
Abstract A number of popular arguments for dualism start from a premise about an epistemic gap between physical truths and truths about consciousness, and infer an ontological gap between physical processes and consciousness. Arguments of this sort include the conceivability argument, the knowledge argument, the explanatory gap argument,
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source