Results 101 to 110 of about 24,124,459 (297)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dynamics of Vortices in Two-Dimensional Magnets

, 1999
Theories, simulations and experiments on vortex dynamics in quasi-two-dimensional magnetic materials are reviewed. These materials can be modelled by the classical two-dimensional anisotropic Heisenberg model with XY (easy-plane) symmetry.
Two-dimensional Magnets, Franz G. Mertens, A. R. Bishop   +2 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The development of integrated circuits based on two-dimensional materials

, 2021
Two-dimensional (2D) materials could potentially be used to develop advanced monolithic integrated circuits. However, despite impressive demonstrations of single devices and simple circuits—in some cases with performance superior to those of silicon ...
Zhang, Xixiang, Zhu, Kaichen, Xu, Xiangming, Wen, Chao, Alshareef, Husam N., Lanza, Mario, Xue, Fei, Aljarb, Areej A., Tung, Vincent   +8 more
core   +1 more source

Synergistic charge Ti₃CNTₓ@graphene nanoplatelets bi-functional catalyst for efficient water splitting and photocatalytic dyes and antibiotic removal

Chemical Engineering Journal. Green and Sustainable
Catalytic activity is studied as a potential remedy for environmental pollution issues caused by industrial contaminants. This work successfully synthesized a novel Ti3CNTx@Graphene Nanoplatelets (GNPs) composite catalyst prepared using a liquid-phase ...
Farkhanda Saba, Imran Haider Sajid, Irfan Ali, Syed Irfan, Muhammad Yousaf, Syed Rizwan   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Facet-selective growth of halide perovskite/2D semiconductor van der Waals heterostructures for improved optical gain and lasing

Nature Communications
The tunable properties of halide perovskite/two dimensional (2D) semiconductor mixed-dimensional van der Waals heterostructures offer high flexibility for innovating optoelectronic and photonic devices.
Liqiang Zhang, Yiliu Wang, Anshi Chu, Zhengwei Zhang, Miaomiao Liu, Xiaohua Shen, Bailing Li, Xu Li, Chen Yi, Rong Song, Yingying Liu, Xiujuan Zhuang, Xidong Duan   +12 more
doaj   +1 more source

In situ synthesis of large-area sixfold-oriented Mo6Te6 nanowires networks through hydrogen-assisted annealing of 2H MoTe2 nanosheets

Nano Research
Phase transition and edge structure reconstruction of two-dimensional (2D) materials are critical for modulating their properties and applications. Here, we employ a hydrogen-assisted annealing method to accomplish the extensive transformation from a 2H ...
Ying Huangfu, Ping Lu, Jiang Zhong, Qiankun Zhang, Jingyi Liang, Zhengwei Zhang, Biao Qin, Zucheng Zhang, Ziwei Huang, Wei Li, Kun He, Xiaohui Lin, Xiangdong Yang, Jia Li, Bo Li, Weiyou Yang, Zhang Lin, Liyuan Chai, Xidong Duan   +18 more
doaj   +1 more source