Results 131 to 140 of about 31,594,956 (291)
Numerical study of thermally stratified flows of a fluid overlying a highly porous material
, 2014 In this talk we are concerned with thermally stratified flows in domains that contain a macroscopic interface between a highly porous material and a pure-fluid domain.
Antoniadis, Panagiotis +2 more
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Numerical simulation of various flow regimes in water delivery systems
Engineering Applications of Computational Fluid MechanicsTransient flow frequently occurs in water delivery systems, including various flow regimes such as water hammer, free surface flow, and slug flow. Current models often oversimplify these phenomena by simulating single-phase flow or using simplistic one ...
YinYing Hu +6 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Two fluid model in low energy excited states within spin-ice systems. [PDF]
Sci Rep, 2018 López-Bara FI, López-Aguilar F.
europepmc +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
MathematicsThis contribution underscores the importance of selecting an appropriate interphase momentum transfer model for accurately predicting the distribution of the solid phase in a full-scale circulating fluidized bed (CFB) riser equipped with a smooth C-type ...
Aldo Germán Benavides-Morán +1 more
doaj +1 more source
Turbulent Aggregation and Deposition Mechanism of Respirable Dust Pollutants under Wet Dedusting using a Two-Fluid Model with the Population Balance Method. [PDF]
Int J Environ Res Public Health, 2019 Wang P, Shen S, Zhou L, Liu D.
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source