Results 111 to 120 of about 31,594,956 (291)
ON INTERACTION BETWEEN FALLING BODIES AND THE SURROUNDING FLUID [PDF]
, 2010 Interactions between a finite number of bodies and the surrounding fluid, in a channel for instance, are investigated theoretically. In the planar model here the bodies or modelled grains are thin solid bodies free to move in a nearly parallel formation ...
Ellis, AS, Smith, FT
core
Fluid-particle dynamics of nasal drug delivery in a realistic human airway lung model
, 2022 Nasal drug delivery provides a rapid onset of therapeutic effects due to the nasal route's large surface area, high blood flow, and ease of accessibility.
Francis, Isabella +3 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
On Grid-Generated Quantum Turbulence
EntropyNearly homogeneous and isotropic turbulence, generated in flows through grids of various forms in wind tunnels or by towing or oscillating grids in stationary samples of classical viscous fluids and the superfluid phases of helium, have played an ...
Ladislav Skrbek
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A Verification of the Two-Fluid Model with Interfacial Inertial Coupling
FluidsThe two-fluid model (TFM) has become a foundational tool in numerical codes used for engineering analyses of two-phase flows in energy systems. However, its completeness remains a topic of debate because improper modeling of interfacial inertial coupling
Raghav Ram +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Applying a Modified Two-Fluid Model to Numerical Simulation of Two-Phase Flow in the Membrane Chlor-Alkali Cells [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2008 In this study, gas evolution in a vertical electrochemical cell is investigated numerically with a modified two-fluid model. The mathematical model involves solution of separate transport equation for the gas and liquid phases with an allowance to inter ...
Farshad Abbasi, Hasan Rahimzadeh
doaj