Results 121 to 130 of about 31,594,956 (291)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

21st Australasian Fluid Mechanics Conference (AFMC 2018)

, 2018
Fluid Structure Interactions (FSI), if not managed appropriately are known to have contributed to the loss of several aerospace vehicles. As done for the X-43, FSI can be designed-out by making structures sufficiently rigid and by providing appropriate ...
Jacobs, P., Jahn, I.H.J., Currao, G.M.D., Gollan, R., Neely, A.J.   +4 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A posteriori study of filtered Euler-Euler two-phase model using a high resolution simulation of a 3D periodic circulating fluidized bed [PDF]

Gas-particle flows in vertical risers are involved in many industrial scale fluidized bed applications such as catalytic cracking, fossil or biomass combustion. Risers flows are often simulated by two-fluid model equations coupled with closures developed
Simonin, Olivier, Fede, Pascal, Özel, Ali   +2 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Identification of dangerous LNG sloshing using a rapid sloshing model validated with computational fluid dynamics

, 2008
A non-linear pendulum model is developed to represent the motion of a sloshing fluid in real time. The forces imposed by the sloshing fluid are identified using multiphase RANS CFD simulations and subsequently included in the pendulum sloshing model. The
Godderidge, Bernhard, Earl, Chris, Turnock, Stephen, Tan, Mingyi   +3 more
core   +1 more source

Numerical Simulation of Epidemic Prevention and Ventilation Efficiency in Indoor Spaces with Partitions and an Air curtain

Journal of Applied Science and Engineering
In this study, computational fluid dynamics (CFD) were used to simulate the effect of a partition and air curtain on the concentration of a pollution source in an indoor space with different ventilation configurations. First, in the partition simulation,
Kun-Liang Hsieh, Yu-Hsuan Lee, Che-Yin Lee, Shu-Yu Peng, Shi-Min Lee   +4 more
doaj  

Fluid Structure Interaction (FSI) simulation of the human eye under the air puff tonometry using Computational Fluid Dynamics (CFD) [PDF]

, 2018
The air puff test is a non-contact method used in different areas to investigate the material behaviour or the biomechanical properties of biological tissues such as skin, cornea, and soft tissue tumours and also to study fruit firmness or meat ...
Theofilis, V., Maklad, Osama, Elsheikh, A.   +2 more
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source