Results 71 to 80 of about 36,788,951 (244)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

An Energy Management System of a Fuel Cell/Battery Hybrid Boat [PDF]

, 2014
All-electric ships are now a standard offering for energy/propulsion systems in boats. In this context, integrating fuel cells (FCs) as power sources in hybrid energy systems can be an interesting solution because of their high efficiency and low ...
HAN, Jingang, CHARPENTIER, Jean-Frederic, Jean-Frederic Charpentier, TANG, Tianhao, Tianhao Tang, Jingang Han   +5 more
core   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Nonlinear robust sliding mode - Backstepping hybrid control for WECS -theoretical design and experimental evaluation

Heliyon
This paper proposes a new contribution in the field of optimizing control techniques for wind systems to enhance the quality of the energy produced in the grid.
Farah Echiheb, Ismail Elkafazi, Badre Bossoufi, Brahim El bhiri, Mishari Metab Almalki, Thamer A.H.Alghamdi   +5 more
doaj   +1 more source

Solid Oxide Fuel Cell Hybrid System for Distributed Power Generation [PDF]

, 2004
This report summarizes the work performed by Hybrid Power Generation Systems, LLC (HPGS) during the April to October 2004 reporting period in Task 2.3 (SOFC Scaleup for Hybrid and Fuel Cell Systems) under Cooperative Agreement DE-FC26-01NT40779 for the U.
Deangelis, David, Peter, Max, Rahman, Faress, Sokolov, Pavel, Depuy, Rich, Karvountzi, Georgia, Yang, Deliang, Dey, Debashis, Minh, Nguyen   +8 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A comprehensive review of optimizing hybrid renewable energy system using optimization techniques

Engineering Science and Technology, an International Journal
The increasing penetration of renewable energy sources has introduced significant challenges due to their inherent intermittency and uncertainty. Hybrid renewable energy systems have emerged as an effective solution to enhance power supply reliability ...
Ye Yao, Zhen Wang, Chao Ma, Mengmeng Liu, Wenchao Qi, Xiuwei Yang, Xifeng Gao, Yingzhou Liu, Jijian Lian, Haolin Wang   +9 more
doaj   +1 more source

Optimization-Based Methods for Nonlinear and Hybrid Systems Verification [PDF]

, 2005
Complex behaviors that can be exhibited by hybrid systems make the verification of such systems both important and challenging. Due to the infinite number of possibilities taken by the continuous state and the uncertainties in the system, exhaustive ...
Prajna, Stephen
core   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source