Results 91 to 100 of about 397,923 (311)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A cold strontium Rydberg gas [PDF]

, 2011
Cold gases of Rydberg atoms are an ideal system in which to study the novel effects of strong interatomic interactions. This thesis describes the design and construction of the world's first experiment to study Rydberg states in a cold gas of an alkaline
MILLEN, JAMES
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Dynamics of quantum correlations for two mode entangled coherent fields

Results in Physics, 2017
We investigate the quantum correlation dynamics of two separated continuous variable systems for which, the system comprises a pair of two-level atoms coupled to two cavities.
Tesfay Gebremariam, Yexiong Zeng, Chong Li   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Photon transport in a gas of two-level atoms: unveiling quantum light creation

New Journal of Physics
We present a theoretical analysis of nearly monochromatic light propagation through a gas of two-level atoms using the Heisenberg–Langevin equation method.
L Yatsenko, M Cordier, L Pache, M Schemmer, P Schneeweiss, J Volz, A Rauschenbeutel   +6 more
doaj   +1 more source

Dynamics of atom-atom entanglement in two-atom model with degenerate two-photon raman transitions

Вестник Самарского университета: Естественнонаучная серия
The exact dynamics of a model consisting of two two-level atoms interacting with the electromagnetic field mode of an ideal resonator through degenerate Raman transitions are found for coherent and thermal field states.
A. Othman, E. K. Bashkirov
doaj   +1 more source

A microscopic theory of photonucleation: Density functional approach to the properties of a fluid of two-level atoms, a part of which is excited

Condensed Matter Physics, 2006
We use the density functional method to examine the properties of the nonuniform (two-phase) fluid of two-level atoms, a part of which is excited. We calculate the nucleation barrier for vapor-to-liquid phase transition in the presence of excited atoms.
O.Derzhko, V.Myhal
doaj   +1 more source

Realisation of a cold mixture of rubidium and caesium [PDF]

, 2008
This thesis describes a new apparatus designed to study cold, ultracold, and quantum degenerate mixtures of rubidium and caesium atoms. The Rb- Cs mixture is prepared using a double magneto-optical trap (MOT) system in which a two-species pyramid MOT ...
Harris, Magaret L, Harris, Margaret L.
core