Results 61 to 70 of about 329,485 (247)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Design and Modelling of a Two-Axis Compliant Joint Based on Flexure Leaf Springs

Machines
In the field of parallel robots, traditional rigid joints compromise motion accuracy owing to inherent friction and backlash, thus driving the demand for high-performance compliant joints.
Kuncheng Feng, Hasiaoqier Han, Changzheng Chen, Jiaxin Li, Haifei Hu, Kai Zhang, Zhenbang Xu   +6 more
doaj   +1 more source

Noise-enabled precision measurements of a Duffing nanomechanical resonator

, 2004
We report quantitative experimental measurements of the nonlinear response of a radiofrequency mechanical resonator, with very high quality factor, driven by a large swept-frequency force.
A. N. Cleland, A. H. Nayfeh, J. S. Aldridge, M. Dykman, R. P. Feynman, W. H. Press   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Visual Dynamics: Stochastic Future Generation via Layered Cross Convolutional Networks

, 2019
We study the problem of synthesizing a number of likely future frames from a single input image. In contrast to traditional methods that have tackled this problem in a deterministic or non-parametric way, we propose to model future frames in a ...
Bouman, Katherine L., Freeman, William T., Wu, Jiajun, Xue, Tianfan   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Analysis of the coupling effect of water on deck and parametric rolling motion in regular waves

Zhongguo Jianchuan Yanjiu
ObjectivesParametric rolling and green water on deck are two critical nonlinear phenomena closely related to ship motion stability, particularly under severe sea conditions.
Jiarun ZHANG, Shuxia BU, Yaliu LIU, Liqin LIU, Yilun LIU   +4 more
doaj   +1 more source

Thin shell morphology in the circumstellar medium of massive binaries

, 2010
We investigate the morphology of the collision front between the stellar winds of binary components in two long-period binary systems, one consisting of a hydrogen rich Wolf-Rayet star (WNL) and an O-star and the other of a Luminous Blue Variable (LBV ...
A. J. van Marle, Bouret, Cherchneff, Corcoran, Dgani, Folini, Freyer, Freyer, García-Segura, García-Segura, García-Segura, Langer, Meliani, Mellema, Mokiem, Monnier, Okazaki, Parkin, Parkin, Parkin, Pittard, Pittard, R. Keppens, Smith, Stevens, Townsend, Tóth, van Marle, van Marle, van Marle, van Marle, Varricatt, Vink, Vink, Vishniac, Vishniac, Walder, Z. Meliani   +37 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Unsteady, Free Surface Flows; Solutions Employing the Lagrangian Description of the Motion [PDF]

, 1970
Numerical techniques for the solution of unsteady free surface flows are briefly reviewed and consideration is given to the feasibility of methods involving parametric planes where the position and shape of the free surface are known in advance.
Brennen, Christopher, Whitney, Arthur K.
core