Results 81 to 90 of about 909,795 (277)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

FlectoSol – A pneumatically activable PV-functionalized façade shading module with bending motion in two directions for solar tracking

Developments in the Built Environment
A continuously adjustable façade shading system functionalized with photovoltaics enables, besides adaptive shading, energy harvesting by solar tracking. This requires large bending motion in two directions.
Larissa Born, Edith Anahi González San Martín, Matthias Ridder, Axel Hannes Körner, Jan Knippers, Götz T. Gresser   +5 more
doaj   +1 more source

Thin shell morphology in the circumstellar medium of massive binaries

, 2010
We investigate the morphology of the collision front between the stellar winds of binary components in two long-period binary systems, one consisting of a hydrogen rich Wolf-Rayet star (WNL) and an O-star and the other of a Luminous Blue Variable (LBV ...
A. J. van Marle, Bouret, Cherchneff, Corcoran, Dgani, Folini, Freyer, Freyer, García-Segura, García-Segura, García-Segura, Langer, Meliani, Mellema, Mokiem, Monnier, Okazaki, Parkin, Parkin, Parkin, Pittard, Pittard, R. Keppens, Smith, Stevens, Townsend, Tóth, van Marle, van Marle, van Marle, van Marle, Varricatt, Vink, Vink, Vishniac, Vishniac, Walder, Z. Meliani   +37 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Drgania Parametryczne Jednostopniowej Przekładni Zębatej

Engineering Transactions, 1972
The subject of the investigations is the theoretical analysis of parametric vibrations of a simple gear transmission produced by periodic variations of the toothing rigidity.
R. Gryboś
doaj  

Repeatability of scapular motion tracking in individuals with high body mass index

Frontiers in Sports and Active Living
IntroductionScapular motion tracking is essential for understanding shoulder kinematics, but its utility in individuals with high body mass index (BMI) requires further investigation.
Angelica E. Lang, Angelica E. Lang, Sophia Abiara   +2 more
doaj   +1 more source

Effect of multi-frequency parametric excitations on the dynamics of on-board rotor-bearing systems

, 2020
In the transportation domain such as automotive turbochargers and aircraft turbines, the vibrations of on-board rotors are induced not only by the mass unbalance excitation but also by various movements of their support. The dynamics of an on-board rotor
Y. Briend, M. Dakel, E. Châtelet, Marie-Ange Andrianoely, R. Dufour, S. Baudin   +5 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source