Results 141 to 150 of about 17,766,923 (318)

[Stage Two Landscapes 23]

, 2003
Wet on wet landscape of telephone poles and trees next to road with blue sky.Tiff file: 2040x3000 pixels, 17.5 Mb; Display: jpeg, 510x750 pixels ...
Catich, Father Edward Catich
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

[Stage Two Landscapes 02]

, 2003
Landscape with 1 house and trees, blue and tan foreground, brown and red background, black and blue sky.Tiff file: 1810x2490 pixels, 12.9 Mb; Display: jpeg, 413x569 pixels ...
Father Edward Catich
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

[Stage Two Landscapes 03]

, 2003
Wet on wet landscape of 4 white houses and trees along water with blue sky.Tiff file: 2210x2620 pixels, 16.6 Mb; Display: jpeg, 529x630 pixels ...
Father Edward Catich
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

[Stage Two Landscapes 24]

, 2003
Wet on wet landscape with blue and tan foreground, houses and trees in background and dark blue sky.Tiff file: 4510x3290 pixels, 42.5 Mb; Display: jpeg, 600x394 pixels ...
Father Edward Catich
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

[Stage Two Landscapes 17]

, 2003
Wet on wet landscape with black and white houses and trees; green, rust and yellow foreground; blue and grey sky.Tiff file: 2030x3280 pixels, 19 Mb; Display: jpeg, 495x800 pixels ...
Father Edward Catich
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source