Results 161 to 170 of about 17,766,923 (318)
, 2003 Wet on wet landscape; 3 white, blue and red houses with green windows, pink and green foreground; black and blue sky.Tiff file: 2620x3400 pixels, 25.5 Mb; Display: jpeg, 616x800 pixels ...
Catich, Father Edward Catich
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2003 Wet on wet landscape of many buildings in blue, green, red and white; 2 figures along water and dock with grey, green and blue sky.Tiff file: 2280x3380 pixels, 22.0 Mb; Display: jpeg, 525x800 pixels ...
Father Edward Catich
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2003 Wet on wet landscape of road leading to small building and tower. Green, blue and red foreground; dark blue and purple sky.Tiff file: 2250x3260 pixels, 21 Mb; Display: jpeg, 552x800 pixels ...
Father Edward Catich
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Efficiency of blocking two-stage model-robust and model-sensitive designs. [PDF]
In two-stage experimentation, it is recommended that a block effect is included in the model to capture a possible shift in the mean response between the stages.
Goos, Peter +2 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Experimental Comparison of Multi-Stage and One-Stage Contests [PDF]
This article experimentally studies a two-stage elimination contest and compares its performance with a one-stage contest. Contrary to the theory, the two-stage contest generates higher revenue than the equivalent one-stage contest.
Roman M. Sheremeta
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